For professionals in the chemical industry, a thorough understanding of a compound's properties and safe handling procedures is fundamental to its effective and responsible use. 2-Chloro-4-methyl-3-nitropyridine (CAS 23056-39-5) is one such chemical intermediate, valued for its utility in various synthetic processes, including the production of OLED materials and pharmaceutical intermediates. This article aims to provide a clear overview of its key properties and essential handling guidelines.

Chemical Identity and Physical Properties:

2-Chloro-4-methyl-3-nitropyridine is an organic compound with the molecular formula C6H5ClN2O2 and a molecular weight of approximately 172.57 g/mol. As a typical fine chemical intermediate, it is commonly supplied as an off-white to light yellow crystal or powder. Its physical state at room temperature is solid. Key physical parameters reported include a melting point typically in the range of 51-53°C, and a density of around 1.406 g/cm³. While it exhibits limited solubility in water, it is generally soluble in common organic solvents like chloroform, DMSO, and methanol, which is important for reaction and purification processes.

Reactivity and Applications:

The chemical structure of 2-chloro-4-methyl-3-nitropyridine features a pyridine ring with strategically placed substituents: a chlorine atom, a methyl group, and a nitro group. This combination makes it a versatile intermediate for organic synthesis. The chlorine atom is amenable to nucleophilic substitution and various cross-coupling reactions, enabling the formation of carbon-carbon and carbon-heteroatom bonds. The nitro group can be reduced to an amino group, further expanding its synthetic utility. These reactive sites make it a valuable precursor for complex molecules in fields such as electronics (OLEDs) and pharmaceuticals.

Safety and Handling Precautions:

When handling 2-chloro-4-methyl-3-nitropyridine, it is crucial to adhere to safety best practices. According to GHS classifications, it is often labeled as harmful and an irritant. Hazard statements may include H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Therefore, appropriate personal protective equipment (PPE) is mandatory:

  • Eye Protection: Wear safety glasses with side-shields or goggles.
  • Skin Protection: Use chemical-resistant gloves (e.g., nitrile, neoprene) and protective clothing.
  • Respiratory Protection: Work in a well-ventilated area or use a fume hood. If dust or aerosols are generated, wear a suitable respirator.

It is recommended to store the chemical in a cool, dry place, away from direct sunlight and incompatible materials. Keep containers tightly closed to prevent moisture absorption and contamination, as the compound can be hygroscopic. Users should always consult the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) provided by the manufacturer or supplier for comprehensive safety information and emergency procedures.

Procurement Considerations:

For industrial applications, sourcing high-quality 2-chloro-4-methyl-3-nitropyridine from reliable manufacturers is essential. When you buy this compound, consider factors such as purity specifications, availability of batch-specific Certificates of Analysis (CoA), and the supplier's adherence to quality standards. For bulk purchases, obtaining a competitive price quote from established suppliers in China can be advantageous, provided quality and compliance are maintained.

By understanding and respecting the properties and safety requirements of 2-Chloro-4-methyl-3-nitropyridine, chemists and industrial users can effectively leverage this important intermediate in their synthetic endeavors.