For chemists engaged in organic synthesis, a thorough understanding of the physical and chemical properties of their starting materials and intermediates is fundamental to successful reactions. 1-Bromo-2-(difluoromethoxy)benzene, a key building block, possesses a set of characteristics that make it particularly valuable for various synthetic applications. Knowing these properties, and sourcing from a reliable manufacturer, ensures optimal utilization.

Physically, 1-Bromo-2-(difluoromethoxy)benzene is described as a colorless transparent liquid. This appearance is a primary indicator of its purity. The specific gravity of approximately 1.6 ± 0.1 g/cm³ at 20°C provides insight into its density, which is relevant for volumetric measurements and reaction calculations. Its boiling point of 199.2 ± 30.0 °C at 760 mmHg indicates it is a relatively high-boiling compound, suggesting lower volatility and potentially easier handling under ambient conditions compared to more volatile solvents.

Crucially for safety and process design, the flash point of 88.3 ± 8.8 °C classifies it as a combustible liquid, requiring appropriate precautions during storage and use. The vapor pressure is noted as 0.5 ± 0.4 mmHg at 25°C, further underscoring its low volatility at room temperature. These parameters are essential for assessing fire hazards and designing appropriate ventilation and containment strategies when you buy and handle this compound.

Chemically, the molecular formula C₇H₅BrF₂O and molecular weight of 223.015 point to its structure. The presence of both a bromine atom and a difluoromethoxy group dictates its reactivity. The bromine atom is susceptible to nucleophilic substitution and metal-catalyzed cross-coupling reactions, making it a versatile site for molecular elaboration. The difluoromethoxy group acts as an electron-withdrawing substituent, influencing the reactivity of the aromatic ring and potentially enhancing the stability or modifying the pharmacokinetic profile of molecules synthesized from it.

When seeking to purchase 1-Bromo-2-(difluoromethoxy)benzene, partnering with a reputable supplier in China like NINGBO INNO PHARMCHEM CO.,LTD. is essential. They not only provide materials meeting the specified assay of ≥98.0% but also ensure that critical physical properties are consistently maintained. Understanding these properties allows researchers to better predict reaction outcomes, optimize conditions, and ensure safe laboratory practices. Investing in high-quality intermediates from trusted sources ultimately leads to more efficient and successful synthetic outcomes.