Effective utilization of any chemical reagent hinges on a thorough understanding of its properties and associated safety protocols. 2-[N,N-Bis(trifluoromethylsulfonyl)amino]pyridine, a vital triflating agent with CAS number 145100-50-1, is no exception. This article provides essential information on its characteristics, safety guidelines, and recommended storage conditions, ensuring that researchers and industrial chemists can handle and employ this compound with both efficacy and safety in mind. When you need to buy this reagent, knowing these details will guide your purchase from a reputable manufacturer.

Physically, 2-[N,N-Bis(trifluoromethylsulfonyl)amino]pyridine typically presents as a white to off-white crystalline powder or crystals. Its molecular formula is C7H4F6N2O4S2, with a molecular weight of 358.24 g/mol. Key physical parameters include a melting point range of 40-42 °C and a boiling point of 80-90 °C at a low pressure of 0.25 mm Hg. These specifications, readily available from most suppliers, are important for verifying product identity and quality. The compound’s refractive index is noted as 1.485.

Chemically, the reagent's reactivity is primarily defined by its ability to introduce the triflate group. However, it is also characterized by its sensitivity to moisture. This hygroscopic nature dictates specific handling and storage procedures. Prolonged exposure to atmospheric moisture can lead to hydrolysis, potentially degrading the reagent and diminishing its efficacy in synthesis. Therefore, it is crucial to store 2-[N,N-Bis(trifluoromethylsulfonyl)amino]pyridine in tightly sealed containers in a cool, dry, and well-ventilated place. Refrigeration at +4°C is frequently recommended by manufacturers to maintain its stability and longevity.

Safety is paramount when working with any chemical. 2-[N,N-Bis(trifluoromethylsulfonyl)amino]pyridine is classified as an irritant, with hazard statements including H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment (PPE) should always be worn when handling this compound. This includes safety goggles or a face shield, chemical-resistant gloves (such as nitrile or neoprene), and a lab coat. In areas where dust may be generated, respiratory protection, like an N95 dust mask, is recommended. Always consult the Safety Data Sheet (SDS) provided by your supplier before use, as it contains comprehensive information on hazards, first-aid measures, and spill containment.

For those looking to purchase 2-[N,N-Bis(trifluoromethylsulfonyl)amino]pyridine, understanding these properties and safety guidelines is as important as finding a reliable manufacturer and competitive price. Prioritizing safe handling practices and proper storage ensures the integrity of the reagent and the success of your synthetic endeavors. Always request the SDS and adhere to all recommended safety precautions when working with this potent chemical.