For professionals engaged in chemical synthesis, a thorough understanding of the compounds they work with is essential. 2-Chlorobenzoxazole, bearing the CAS number 615-18-9, is a heterocyclic organic compound with distinct properties that make it a valuable intermediate. This article explores its key chemical and physical characteristics, along with insights into its synthesis and proper handling.

Chemically, 2-Chlorobenzoxazole has the molecular formula C7H4ClNO and a molecular weight of approximately 153.57 g/mol. It is typically described as a colorless to yellow liquid, although some sources mention a melting point of around 7°C, suggesting it can exist as a low-melting solid. Its boiling point is recorded as 201-202°C, and its density is around 1.345 g/mL at 25°C. These physical properties are important for process design and handling. The compound's reactivity stems from the chlorine atom attached to the benzoxazole ring, making it a versatile reagent in organic transformations.

The synthesis of 2-Chlorobenzoxazole can be achieved through various methods. One common route involves the reaction of 2-mercaptobenzoxazole with thionyl chloride (SOCl2) in the presence of a catalyst like DMF. Following the reaction, purification via column chromatography typically yields the desired product. Understanding these synthesis pathways helps in appreciating the manufacturing process and potential impurities.

Proper storage and handling are also critical for maintaining the integrity of 2-Chlorobenzoxazole. It is generally recommended to store it in a tightly closed container, away from heat, sparks, and open flames. Due to its reactivity, it should be kept in a dry, well-ventilated place, and ideally stored under inert conditions. Adhering to these guidelines ensures the compound remains stable and suitable for its intended applications in pharmaceutical, agrochemical, and organic synthesis.

NINGBO INNO PHARMCHEM CO.,LTD. as a dedicated chemical supplier, ensures that 2-Chlorobenzoxazole provided meets high purity standards. We aim to equip our clients with not only the chemical itself but also the knowledge to use it effectively and safely, supporting their ongoing research and production endeavors.