For chemists and researchers involved in organic synthesis, a thorough understanding of chemical intermediates is vital. N-(3-Aminopropyl)-imidazole, bearing the CAS number 5036-48-6, is a compound that offers unique chemical reactivity and structural attributes, making it a valuable asset in various synthetic pathways. This article delves into its key properties, common synthesis routes, and important handling considerations for professionals in the field.

Physically, N-(3-Aminopropyl)-imidazole presents as a clear, colorless liquid. Its miscibility with water is a significant advantage for reactions conducted in aqueous or mixed solvent systems. Key physical properties include a melting point of -68 °C and a boiling point of 296 °C. The density is approximately 1.049 g/mL at 25 °C, and its refractive index (n20/D) is around 1.519. These characteristics are crucial for chemists to consider during process design and material handling. The compound is also sensitive to air, necessitating storage under an inert atmosphere to maintain its integrity.

In terms of synthesis, N-(3-Aminopropyl)-imidazole can be prepared through several routes. Common precursors include imidazole, acrylonitrile, and ammonia, often utilizing catalytic processes. For example, one method involves the reaction of imidazole with acrylonitrile followed by reduction, or direct amination routes. Understanding these synthesis pathways allows researchers to better appreciate the manufacturing processes and potential impurities. When sourcing this compound, inquiring about the synthesis method can provide additional confidence in the product's quality and suitability for specific applications.

For R&D scientists looking to buy N-(3-Aminopropyl)-imidazole, obtaining it from a reputable N-(3-Aminopropyl)-imidazole manufacturer or N-(3-Aminopropyl)-imidazole supplier is essential. Factors such as purity (often specified as >97% via GC) and proper storage conditions (cool, dry, dark place, under inert atmosphere) are critical. The N-(3-Aminopropyl)-imidazole price will be influenced by these specifications and the quantity purchased. Consulting a detailed Safety Data Sheet (SDS) is also a mandatory step for safe handling, as the compound can cause severe skin burns and eye damage.

By familiarizing themselves with the properties and synthesis of N-(3-Aminopropyl)-imidazole (CAS 5036-48-6), chemists can effectively integrate it into their research and development workflows, ensuring efficient and successful outcomes in their chemical projects.