The field of targeted protein degradation has been revolutionized by the advent of Proteolysis Targeting Chimeras (PROTACs). These bifunctional molecules leverage the cell's natural ubiquitin-proteasome system to selectively degrade disease-causing proteins. Central to the design of effective PROTACs is the linker molecule, which connects the protein of interest (POI) binder to the E3 ligase binder. Among the most versatile and widely used linkers are those based on polyethylene glycol (PEG), and Diethylene Glycol Ditosylate (CAS 7460-82-4) stands out as a critical component.

Diethylene Glycol Ditosylate, a ditosylated derivative of diethylene glycol, offers a precisely defined length and flexibility, crucial for optimal PROTAC architecture. The tosylate groups serve as excellent leaving groups, facilitating conjugation reactions during the synthesis of complex molecules. The chemical structure, featuring an ether linkage flanked by two ethyl tosylate moieties, provides a balance of hydrophilicity and a controllable chain length, which can significantly impact a PROTAC's solubility, cell permeability, and binding affinity. For researchers and procurement managers involved in drug discovery and development, securing a reliable supply of high-purity Diethylene Glycol Ditosylate is paramount.

As a leading manufacturer and supplier of fine chemical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. offers Diethylene Glycol Ditosylate with a guaranteed purity of ≥98% by HPLC. Our commitment to quality ensures that scientists can confidently incorporate our product into their PROTAC synthesis workflows without concerns about impurities affecting reaction outcomes or final product efficacy. We understand the critical nature of these building blocks in advancing therapeutic research, and our production processes are geared towards meeting the highest industry standards. If you are looking to buy Diethylene Glycol Ditosylate for your PROTAC projects, consider us as your trusted supplier in China.

The synthesis of PROTACs often involves multiple coupling steps, and the reliability of each intermediate directly influences the overall yield and success of the project. Diethylene Glycol Ditosylate, with its well-defined reactivity, is amenable to various conjugation chemistries, including nucleophilic substitution reactions with amines or thiols. This versatility makes it a preferred choice for chemists designing novel PROTAC payloads. We encourage R&D scientists and procurement specialists to explore our product specifications and inquire about our wholesale price for high purity PEG linker for synthesis. Our team is ready to assist with technical queries and to provide quotations for bulk orders, ensuring your research and development pipeline remains uninterrupted. Partner with NINGBO INNO PHARMCHEM CO.,LTD. for your critical chemical intermediate needs and accelerate your journey in targeted protein degradation.