The pyrimidine nucleus is a recurring structural motif in many compounds of significant biological and chemical interest. Understanding the synthesis and properties of key pyrimidine derivatives is crucial for advancing various fields, from medicinal chemistry to materials science. This article delves into the synthesis and physicochemical characteristics of 6-Oxo-3H-pyrimidine-4-carboxylic acid (CAS 6299-87-2), a compound that plays a vital role as a chemical intermediate.

The synthesis of 6-Oxo-3H-pyrimidine-4-carboxylic acid typically involves cyclization reactions utilizing readily available precursors. While specific industrial routes can vary, common methods often leverage condensation reactions to construct the pyrimidine ring system. For instance, reactions involving amidines and beta-keto esters or related derivatives are frequently employed. The resulting product is usually isolated and purified to achieve high purity levels, often exceeding 98% as determined by analytical techniques like High-Performance Liquid Chromatography (HPLC). This meticulous purification process is essential for its intended applications.

In terms of physicochemical properties, 6-Oxo-3H-pyrimidine-4-carboxylic acid presents as a white to off-white powder. Its melting point, typically reported in the range of 268-270 °C, signifies a thermally stable solid. These characteristics are important for handling, storage, and formulation in various chemical processes. The compound's molecular formula, C5H4N2O3, and molecular weight of approximately 140.10 g/mol are fundamental identifiers for chemists and researchers. Access to this detailed chemical data from suppliers is indispensable for planning research and development activities.

The importance of 6-Oxo-3H-pyrimidine-4-carboxylic acid is further amplified by its role as a versatile intermediate. It serves as a critical starting material for the synthesis of numerous complex organic molecules, including those with potential pharmaceutical activity. The ability to source this compound from reliable manufacturers, often found in China, allows for its widespread use in both academic and industrial laboratories. By understanding its synthesis and properties, scientists can effectively harness its potential for innovative chemical development and product realization.