In the dynamic field of organic synthesis, the availability of well-defined and reactive building blocks is crucial for innovation. 1-Bromo-3-fluoro-5-iodobenzene, identified by its CAS number 845866-85-5, stands out as a particularly valuable compound due to its unique tri-halogenated aromatic structure. This characteristic allows chemists to perform selective reactions, making it a cornerstone for constructing complex molecules used in pharmaceuticals, agrochemicals, and advanced materials. For any scientist or procurement manager looking to buy this compound, understanding its role in modern synthesis is key to appreciating its value and ensuring the selection of a reliable manufacturer.

A Multifunctional Synthon for Targeted Synthesis

The power of 1-Bromo-3-fluoro-5-iodobenzene lies in the differential reactivity of its three halogen substituents. Bromine, fluorine, and iodine each possess distinct electronegativities and bond strengths, allowing for sequential and site-specific transformations. For instance, the C-I bond is typically the most reactive in many palladium-catalyzed cross-coupling reactions, followed by the C-Br bond. The C-F bond, being stronger, often remains intact or can be activated under specific conditions, providing a handle for subsequent fluorination chemistry or stability to the final molecule. This inherent selectivity makes it an ideal starting material for chemists aiming to introduce precise functional groups or create intricate molecular frameworks.

Key synthetic transformations where this compound excels include:

  • Suzuki-Miyaura Coupling: Reacting the aryl halide with organoboron compounds to form new carbon-carbon bonds.
  • Sonogashira Coupling: Coupling with terminal alkynes to introduce alkyne functionalities.
  • Heck Reaction: Addition of aryl halides to alkenes to form substituted alkenes.
  • Buchwald-Hartwig Amination: Formation of carbon-nitrogen bonds by reacting with amines.

These reactions are fundamental in creating the complex molecular structures required for many biologically active compounds and advanced materials. As such, the demand for high-purity 1-Bromo-3-fluoro-5-iodobenzene from quality manufacturers remains consistently high.

Procurement Insights for Buyers

When procurement professionals search for a supplier of 1-Bromo-3-fluoro-5-iodobenzene (CAS 845866-85-5), they are looking for more than just the chemical itself. They seek a partner who can provide consistent quality, reliable delivery, and competitive pricing. Sourcing from manufacturers in China, known for their extensive chemical production capabilities, can offer significant advantages. Key aspects to evaluate in a potential supplier include:

  • Purity Levels: Ensuring the product meets the required purity (often 95% or more) for successful synthesis.
  • Technical Data: Availability of detailed specifications, including molecular formula (C6H3BrFI), molecular weight (300.90), boiling point (242°C), and flash point (100.1°C).
  • Certificates of Analysis (CoA): Documentation confirming batch-specific quality.
  • Packaging and Shipping: Options for various quantities and efficient global logistics.
  • Customer Support: Responsiveness and technical expertise from the manufacturer or supplier.

By carefully selecting a manufacturer that prioritizes these aspects, buyers can ensure they are obtaining a critical intermediate that will reliably contribute to their research and production goals. The accessibility of 1-Bromo-3-fluoro-5-iodobenzene from reputable sources empowers chemists to push the boundaries of molecular design and chemical innovation.