Organic synthesis is the bedrock of innovation in chemistry, enabling the creation of novel materials, pharmaceuticals, and agrochemicals. At the heart of this discipline are versatile chemical intermediates, and 3-Bromo-1,2-dimethylbenzene (CAS 576-23-8) stands out as a prime example. This article delves into the chemical characteristics and synthetic applications of this key compound, providing insights for chemists and researchers looking to procure this essential building block.

Chemical Profile of 3-Bromo-1,2-dimethylbenzene

Known also as 2,3-Dimethylbromobenzene, this compound presents itself as a clear, colorless to pale yellow liquid. Its molecular formula is C8H9Br, with a molecular weight of 185.06 g/mol. The structure features a benzene ring substituted with two methyl groups at the 1 and 2 positions and a bromine atom at the 3 position. This specific arrangement confers unique reactivity, making it an attractive substrate for a variety of chemical transformations.

Synthetic Utility and Reactions

The presence of the bromine atom on the aromatic ring is the key to its utility in organic synthesis. This halogen atom can be readily displaced by various nucleophiles through nucleophilic aromatic substitution reactions, or it can participate in metal-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira couplings). These reactions allow for the efficient introduction of carbon-carbon or carbon-heteroatom bonds, paving the way for the construction of more complex molecular architectures.

  • Cross-Coupling Reactions: 3-Bromo-1,2-dimethylbenzene is an excellent substrate for palladium-catalyzed cross-coupling reactions, enabling the synthesis of biaryls, styrenes, and alkynes, which are common motifs in pharmaceuticals and advanced materials. Chemists can effectively buy this intermediate to perform these transformations with high yields.
  • Grignard Reagent Formation: It can be converted into its corresponding Grignard reagent, a potent nucleophile widely used in forming new carbon-carbon bonds by reacting with carbonyl compounds, epoxides, and other electrophiles.
  • Directed Lithiation: The methyl groups can influence regioselective functionalization, allowing for precise modifications of the aromatic core.

Applications in Research and Development

Researchers frequently employ 3-Bromo-1,2-dimethylbenzene as a starting material for synthesizing target molecules in medicinal chemistry, materials science, and agrochemical research. Its availability from reputable suppliers, particularly those in China, makes it accessible for both laboratory-scale experiments and larger developmental projects. The ability to obtain this compound at a reasonable price further encourages its widespread use in R&D.

Procurement and Best Practices

When specifying 3-Bromo-1,2-dimethylbenzene for your synthesis needs, it is vital to partner with a reliable manufacturer. Look for suppliers who can provide detailed specifications, including CAS number (576-23-8), purity (e.g., >98% GC), and safety data sheets (SDS). Companies like NINGBO INNO PHARMCHEM CO.,LTD. offer this crucial intermediate, ensuring quality and a consistent supply chain for your ongoing research and synthesis projects.

In summary, 3-Bromo-1,2-dimethylbenzene is an indispensable tool in the arsenal of synthetic organic chemists. Its predictable reactivity and broad applicability in forming complex molecular structures make it a cornerstone for driving innovation in chemical research and development. Ensure your supply by contacting trusted providers for this key organic building block.