The pharmaceutical industry relies heavily on a diverse array of chemical intermediates to synthesize life-saving drugs and novel therapeutic agents. Among these crucial building blocks is 1,3-Dichloro-6-Trifluoromethoxybenzene, known by its CAS number 451-85-4. This article explores its significance in pharmaceutical synthesis and what researchers and procurement specialists should know when looking to purchase this compound.

1,3-Dichloro-6-Trifluoromethoxybenzene: A Key Pharmaceutical Intermediate

1,3-Dichloro-6-Trifluoromethoxybenzene, also referred to as 2,4-Dichloro-1-(trifluoromethoxy)benzene, possesses a unique chemical structure that makes it highly sought after in medicinal chemistry. The presence of halogen atoms (chlorine) and the trifluoromethoxy group confers specific electronic and lipophilic properties to molecules synthesized using this intermediate. These characteristics are often instrumental in modulating a drug candidate's pharmacokinetic profile, including its absorption, distribution, metabolism, and excretion (ADME) properties.

Impact on Drug Development

As a synthetic precursor, 1,3-Dichloro-6-Trifluoromethoxybenzene can be incorporated into various drug scaffolds. Its reactivity allows for further functionalization, enabling chemists to construct complex molecular architectures. This flexibility is vital for:

  • Modulating Bioavailability: The lipophilic nature imparted by the trifluoromethoxy group can enhance a drug's ability to cross cell membranes.
  • Improving Metabolic Stability: Fluorine atoms can often increase a molecule's resistance to metabolic degradation, leading to a longer duration of action.
  • Fine-tuning Receptor Binding: The precise placement of substituents on the benzene ring can influence how a drug interacts with its biological target.

Researchers and R&D departments actively seek out high-purity sources of this intermediate to ensure the success of their synthesis routes and the quality of their final drug products. When you plan to buy 1,3-Dichloro-6-Trifluoromethoxybenzene, prioritizing suppliers who can guarantee high purity and consistent quality is essential.

Procurement Considerations for Pharmaceutical Professionals

For pharmaceutical companies and contract research organizations (CROs), sourcing 1,3-Dichloro-6-Trifluoromethoxybenzene (CAS 451-85-4) involves careful vendor selection. Key considerations include:

  • Quality Assurance: Suppliers must provide detailed product specifications, including purity assays and compliance with relevant pharmacopoeial standards (e.g., USP, BP).
  • Supply Chain Reliability: Ensuring a consistent and uninterrupted supply is critical for ongoing drug development projects. Working with manufacturers that have robust production capacities and efficient logistics is key.
  • Regulatory Compliance: Understanding the regulatory landscape and ensuring that the supplier can provide the necessary documentation for pharmaceutical manufacturing is important.
  • Technical Support: Access to technical experts from the supplier can be invaluable for troubleshooting synthesis challenges.

By partnering with reputable manufacturers and suppliers, particularly those with a strong presence in chemical production such as China, pharmaceutical companies can secure a dependable supply of 1,3-Dichloro-6-Trifluoromethoxybenzene. If your research requires this vital intermediate, reaching out to established chemical suppliers for quotes and product details is a recommended first step.