In the intricate world of chemical synthesis, specific molecules stand out for their utility and versatility. 1,1,2,2-Tetrafluoro-1,2-diiodoethane, identified by CAS number 354-65-4, is one such compound. Its unique structure, featuring a perfluorinated ethane backbone with iodine atoms at each carbon, positions it as a critical intermediate for researchers and industrial chemists alike. Understanding its properties and applications is key to leveraging its full potential in modern synthesis.

Chemical Profile of CAS 354-65-4

1,1,2,2-Tetrafluoro-1,2-diiodoethane (C2F4I2) is a clear pink to dark purple liquid at room temperature. It boasts a relatively low melting point of -21°C and a boiling point in the range of 112-113°C. Its density is approximately 2.629 g/cm³, and its refractive index is around 1.494-1.499. These physical characteristics are important for handling and processing in laboratory and industrial settings.

Chemically, the presence of both highly electronegative fluorine atoms and reactive iodine atoms makes this molecule a potent reagent. The C-I bonds are susceptible to nucleophilic attack and can participate in various coupling reactions, while the fluorinated backbone imparts unique electronic and steric properties to the resulting molecules.

Applications in Advanced Chemistry

The significance of 1,1,2,2-tetrafluoro-1,2-diiodoethane lies in its diverse applications as a synthetic precursor:

  • Fluorination Reactions: It can serve as a source of fluorine or fluorinated fragments in the synthesis of complex fluorinated organic compounds, which are highly sought after in pharmaceuticals, agrochemicals, and materials science due to their enhanced thermal stability, lipophilicity, and metabolic resistance.
  • Coupling Reactions: The iodine atoms can be readily displaced or involved in radical reactions, making it useful in various cross-coupling methodologies to build carbon-carbon or carbon-heteroatom bonds. This allows for the construction of intricate molecular architectures.
  • Perfluoroalkylation: It is an excellent reagent for introducing the -CF2CF2I or related perfluorinated segments into organic molecules, thereby modifying their physical and chemical properties.
  • Material Precursors: Its use extends to the development of specialized polymers and functional materials, where the perfluorinated structure contributes to properties like low surface energy and high chemical resistance.

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