The Science Behind N-Succinimidyl Myristate: Structure, Properties, and Applications
N-Succinimidyl Myristate is a chemical compound that has garnered significant attention in scientific research due to its unique structure and versatile applications. Understanding its scientific basis – from its chemical formula and structure to its physical properties and reactivity – is key to leveraging its full potential. As a trusted supplier in China, we aim to provide comprehensive information about this important reagent.
Chemically, N-Succinimidyl Myristate is an ester formed between myristic acid (a saturated fatty acid with a 14-carbon chain) and N-hydroxysuccinimide. Its molecular formula is C18H31NO4, and its CAS number is 69888-86-4. The structure features a long hydrophobic alkyl chain from myristic acid, linked via an ester bond to the succinimide ring. This specific structure dictates its reactivity and applications. The N-hydroxysuccinimide portion is an activated ester, making it a good leaving group in nucleophilic substitution reactions.
Key physical properties of N-Succinimidyl Myristate typically include its appearance as a white to off-white crystalline powder. Its melting point is usually reported in the range of 80-81°C, indicating a stable solid at room temperature. It exhibits solubility in common organic solvents like acetone, dichloromethane, and toluene, which is essential for its use in solution-phase reactions. Its stability under appropriate storage conditions (often recommended at -20°C) ensures its long-term utility.
The primary scientific application of N-Succinimidyl Myristate is in bioconjugation and chemical synthesis. The activated ester readily reacts with primary amines to form stable amide bonds. This reaction is widely employed for:
1. Protein and Peptide Modification: Attaching labels, drugs, or other functional moieties to proteins and peptides.
2. Lipid Conjugation: Increasing the lipophilicity of molecules by introducing the myristoyl chain.
3. Surface Functionalization: Modifying surfaces in material science to enhance biocompatibility or specific binding properties.
As a premier supplier in China, we ensure that our N-Succinimidyl Myristate meets high purity standards, typically above 98% as determined by HPLC. This commitment to quality guarantees reliable and reproducible results for researchers engaged in these sophisticated chemical processes. By understanding the science behind N-Succinimidyl Myristate, scientists can more effectively integrate it into their experimental designs.
Chemically, N-Succinimidyl Myristate is an ester formed between myristic acid (a saturated fatty acid with a 14-carbon chain) and N-hydroxysuccinimide. Its molecular formula is C18H31NO4, and its CAS number is 69888-86-4. The structure features a long hydrophobic alkyl chain from myristic acid, linked via an ester bond to the succinimide ring. This specific structure dictates its reactivity and applications. The N-hydroxysuccinimide portion is an activated ester, making it a good leaving group in nucleophilic substitution reactions.
Key physical properties of N-Succinimidyl Myristate typically include its appearance as a white to off-white crystalline powder. Its melting point is usually reported in the range of 80-81°C, indicating a stable solid at room temperature. It exhibits solubility in common organic solvents like acetone, dichloromethane, and toluene, which is essential for its use in solution-phase reactions. Its stability under appropriate storage conditions (often recommended at -20°C) ensures its long-term utility.
The primary scientific application of N-Succinimidyl Myristate is in bioconjugation and chemical synthesis. The activated ester readily reacts with primary amines to form stable amide bonds. This reaction is widely employed for:
1. Protein and Peptide Modification: Attaching labels, drugs, or other functional moieties to proteins and peptides.
2. Lipid Conjugation: Increasing the lipophilicity of molecules by introducing the myristoyl chain.
3. Surface Functionalization: Modifying surfaces in material science to enhance biocompatibility or specific binding properties.
As a premier supplier in China, we ensure that our N-Succinimidyl Myristate meets high purity standards, typically above 98% as determined by HPLC. This commitment to quality guarantees reliable and reproducible results for researchers engaged in these sophisticated chemical processes. By understanding the science behind N-Succinimidyl Myristate, scientists can more effectively integrate it into their experimental designs.
Perspectives & Insights
Logic Thinker AI
“Key physical properties of N-Succinimidyl Myristate typically include its appearance as a white to off-white crystalline powder.”
Molecule Spark 2025
“Its melting point is usually reported in the range of 80-81°C, indicating a stable solid at room temperature.”
Alpha Pioneer 01
“It exhibits solubility in common organic solvents like acetone, dichloromethane, and toluene, which is essential for its use in solution-phase reactions.”