The efficacy of oral solid dosage forms, such as tablets and capsules, hinges significantly on the performance of their excipients. Among these, disintegrants play a crucial role in ensuring that the dosage form breaks apart rapidly upon contact with physiological fluids, allowing for the release and absorption of the active pharmaceutical ingredient (API). Sodium Glycolate, a salt of glycolic acid with CAS number 2836-32-0, has proven to be a highly effective pharmaceutical excipient, widely employed as a disintegrant and gelling agent.

As a pharmaceutical grade dissolution excipient, Sodium Glycolate is prized for its rapid water absorption capabilities. When incorporated into tablet formulations, it swells considerably, leading to the swift disintegration of the tablet or granule matrix. This swelling action is fundamental to overcoming the challenges posed by poorly soluble APIs or formulations requiring rapid release. Without an effective disintegrant like Sodium Glycolate, tablets may not dissolve appropriately, potentially decreasing the bioavailability and therapeutic effectiveness of the medication. Therefore, for pharmaceutical manufacturers, securing a consistent and high-quality supply of this excipient is a critical aspect of quality control.

The benefits of using Sodium Glycolate extend to its compatibility with various formulation processes, including direct compression and wet granulation. Its performance as a disintegrant is notably unaffected by the presence of hydrophobic excipients, such as lubricants, which are commonly used in tablet manufacturing. Furthermore, even with increased tablet compression pressures, the disintegration time remains favorably short, showcasing the robustness of Sodium Glycolate as a formulation aid. This makes it a go-to choice for formulators seeking reliable disintegration properties.

For pharmaceutical companies and R&D scientists looking to source this essential excipient, partnering with a reputable manufacturer and supplier is paramount. We are a leading supplier of Sodium Glycolate in China, offering a high-purity product that meets rigorous pharmaceutical standards. Our commitment to quality assurance ensures that each batch of Sodium Glycolate provides predictable and effective disintegration performance. We encourage you to inquire about purchasing Sodium Glycolate for your tablet and capsule formulations, and we can provide detailed specifications and competitive pricing.

In addition to its role as a disintegrant, Sodium Glycolate can also function as a suspending agent, helping to maintain the uniform distribution of insoluble particles in liquid formulations, and as a gelling agent, contributing to desired viscosity profiles. Its versatility underscores its importance in the pharmaceutical excipient landscape. For those seeking to improve tablet dissolution and enhance drug absorption, the incorporation of Sodium Glycolate is a strategic choice.

In summary, Sodium Glycolate (CAS 2836-32-0) is an indispensable pharmaceutical excipient that significantly contributes to the performance of oral solid dosage forms. Its superior disintegrant properties, stemming from its rapid swelling and water uptake, make it a vital component for ensuring the effective delivery of medications. We are dedicated to serving the pharmaceutical industry with high-quality Sodium Glycolate, supporting your formulation development and manufacturing needs.