For R&D scientists and procurement managers in the chemical and pharmaceutical sectors, sourcing high-quality intermediates is paramount. Among these, 3-Chloro-4-fluorophenyl Isothiocyanate (CAS 137724-66-4) stands out as a versatile building block. Understanding where and how to buy this compound can significantly impact project timelines and budget efficiency. This article aims to guide you through the process, highlighting what to look for in a reliable manufacturer and supplier, particularly those based in China.

Understanding 3-Chloro-4-fluorophenyl Isothiocyanate

3-Chloro-4-fluorophenyl Isothiocyanate is an organic compound characterized by its specific chemical structure, featuring chlorine and fluorine atoms on a phenyl ring, along with an isothiocyanate functional group. Its molecular formula is C7H3ClFNS, and it has a molecular weight of approximately 187.62. This intermediate is primarily used in organic synthesis for the creation of more complex molecules, including pharmaceuticals and agrochemicals. Its properties, such as its state as a colorless to pale yellow transparent liquid, and a boiling point of 115-117 °C (at 11 mmHg), are critical for various reaction conditions.

Key Considerations When Buying for Organic Synthesis

When you plan to purchase 3-Chloro-4-fluorophenyl Isothiocyanate, several factors should influence your decision:

  • Purity: For critical synthesis applications, especially in pharmaceuticals, a high purity level (often specified as ≥99.0%) is essential to ensure reaction efficiency and product integrity. Always check the Certificate of Analysis (COA) for lot-specific purity data.
  • Supplier Reliability: Partnering with a reputable manufacturer or supplier is crucial. Look for suppliers with a proven track record, transparent communication, and a strong understanding of chemical manufacturing and quality control. Many international buyers turn to China for cost-effective sourcing, and identifying trusted Chinese chemical suppliers is key.
  • Pricing and Quantity: Competitive pricing is a significant driver for bulk purchases. However, it should not come at the expense of quality. Negotiating pricing for larger quantities or long-term supply agreements can offer substantial cost savings. Understanding minimum order quantities (MOQ) is also important for efficient procurement.
  • Packaging and Shipping: The product is typically supplied in standard packaging, such as 200 kg/drum. Ensure the packaging is appropriate for the chemical's properties (e.g., moisture sensitivity) and that the supplier can handle international shipping regulations effectively.

Sourcing from China: Opportunities and Best Practices

China has emerged as a global hub for chemical manufacturing, offering a wide array of intermediates at competitive prices. When looking to buy 3-Chloro-4-fluorophenyl Isothiocyanate from Chinese manufacturers, it is advisable to:

  • Utilize Chemical Marketplaces: Platforms like ChemicalBook and Echemi can provide lists of manufacturers and suppliers, along with product specifications and pricing.
  • Verify Credentials: Before committing to a large purchase, verify the supplier's credentials, ask for samples, and conduct due diligence to ensure they meet your quality and ethical standards.
  • Direct Communication: Establish direct communication with the sales or technical support teams of potential suppliers. This helps in clarifying product details, asking about synthesis routes, and understanding their manufacturing capabilities.

By carefully considering these aspects, procurement managers and researchers can successfully buy high-quality 3-Chloro-4-fluorophenyl Isothiocyanate, thereby supporting the advancement of their organic synthesis projects.