For procurement managers and R&D scientists in the chemical industry, securing a reliable supply of high-quality intermediates is paramount. 4,4,4-Trifluorobutyronitrile (CAS 690-95-9) is one such compound, prized for its utility in sophisticated organic synthesis, particularly within the pharmaceutical and agrochemical sectors. Understanding its specifications and how to source it effectively can streamline your research and production efforts.

Understanding 4,4,4-Trifluorobutyronitrile: Key Properties

This fluorinated nitrile, with the molecular formula C4H4F3N, presents itself as a colorless transparent liquid. Its critical physical and chemical properties include a boiling point of approximately 139-140°C and a relatively low flash point of 13.1°C, indicating specific handling precautions are necessary. Furthermore, its refractive index stands at 1.324. The most crucial aspect for buyers is its purity, with manufacturers typically offering it at ≥98.0% assay. This high level of purity is essential for ensuring predictable outcomes in complex chemical reactions and for meeting the stringent requirements of pharmaceutical and agrochemical formulations.

Applications Driving Demand

The demand for 4,4,4-Trifluorobutyronitrile is largely driven by its role as a versatile building block. Its trifluoromethyl group (-CF3) is a highly sought-after moiety in medicinal chemistry and crop protection science, as it can significantly influence a molecule's lipophilicity, metabolic stability, and binding affinity. Consequently, it finds extensive use in:

  • Pharmaceutical Synthesis: As an intermediate for novel drug candidates, where the fluorinated structure can enhance bioavailability and therapeutic efficacy.
  • Agrochemical Development: In the creation of advanced pesticides, herbicides, and fungicides, contributing to improved efficacy and targeted action.
  • Specialty Chemical Manufacturing: For various fine chemical applications requiring the unique properties imparted by fluorine atoms.

Sourcing Strategies for Procurement Managers

When looking to buy 4,4,4-Trifluorobutyronitrile, especially in bulk quantities, several factors come into play. Identifying reputable manufacturers in China is often a strategic choice due to the country's robust chemical production infrastructure and competitive pricing. Key considerations when selecting a supplier include:

  • Purity and Quality Control: Always verify the assay percentage and inquire about the supplier's quality assurance processes.
  • Certificate of Analysis (CoA): Ensure a CoA is provided with each batch, detailing the physical and chemical properties and confirming purity.
  • Supply Chain Reliability: A consistent and stable supply is vital for uninterrupted production. Assess the supplier's production capacity and logistical capabilities.
  • Pricing and Quotations: Obtain detailed price information for the quantities you require. Compare offers from multiple trusted suppliers to ensure cost-effectiveness.
  • Technical Support: Good suppliers offer technical assistance, helping you integrate the chemical into your processes efficiently.

By focusing on these aspects, procurement professionals can confidently source high-quality 4,4,4-Trifluorobutyronitrile. As a dedicated chemical supplier, we aim to be your trusted partner, offering competitive pricing and reliable delivery for this critical intermediate. Contact us today for a quote and to discuss your specific requirements for 4,4,4-Trifluorobutyronitrile.