For procurement managers in the chemical and pharmaceutical sectors, securing high-quality intermediates is paramount to the success of research and development projects. Biguanide intermediates, such as 1-(4-Chlorophenyl)biguanide Hydrochloride (CAS 4022-81-5), play a crucial role in the synthesis of various active pharmaceutical ingredients (APIs) and research chemicals. This article provides essential guidance for procurement professionals looking to buy this vital compound.

Understanding Biguanide Intermediates
1-(4-Chlorophenyl)biguanide Hydrochloride, identified by CAS 4022-81-5, is a significant chemical entity. It is recognized for its potential as a dihydrofolate reductase (DHFR) inhibitor, a property that makes it valuable in the exploration of new antimicrobial and anticancer agents. The compound's chemical structure, featuring a biguanide backbone and a chlorophenyl group, contributes to its specific reactivity and potential biological activities.

Key Considerations When Sourcing
When procuring chemicals like 1-(4-Chlorophenyl)biguanide Hydrochloride, several factors are critical:

  1. Purity and Quality: Ensure the supplier provides detailed certificates of analysis (CoA) confirming purity levels, typically 95% or higher for research-grade materials. Consistent quality is essential for reproducible results in synthesis and biological assays.
  2. Supplier Reliability: Partnering with experienced manufacturers and suppliers based in China can offer significant advantages in terms of cost and accessibility. Look for established companies with a proven track record in chemical manufacturing and international trade.
  3. Supply Chain Stability: A consistent and reliable supply chain is crucial for ongoing research and production. Enquire about the manufacturer's production capacity and their ability to meet demand fluctuations.
  4. Pricing and Bulk Discounts: For significant research projects or pilot-scale production, understanding the pricing structure and potential bulk discounts is vital. Direct sourcing from a manufacturer often provides the best value.
  5. Technical Support: Access to technical support from the supplier can be invaluable for understanding product specifications, handling, and potential applications.

Navigating the Procurement Process
To effectively purchase 1-(4-Chlorophenyl)biguanide Hydrochloride, begin by identifying reputable chemical suppliers. Online B2B platforms and industry directories are excellent resources for finding manufacturers in China. When contacting potential suppliers, clearly state your requirements, including CAS number, desired purity, quantity, and any specific packaging needs. Requesting a free sample can also be a good practice to verify product quality before placing a large order.

The Role of DHFR Inhibition
The significance of 1-(4-Chlorophenyl)biguanide Hydrochloride is amplified by its role as a dihydrofolate reductase (DHFR) inhibitor. DHFR is a critical enzyme in the folate metabolic pathway, essential for cell growth and division. Inhibiting DHFR is a well-established strategy in the development of both antimicrobial and anticancer drugs. This makes compounds like 1-(4-Chlorophenyl)biguanide Hydrochloride highly sought after in medicinal chemistry research.

Conclusion
Sourcing essential chemical intermediates requires a strategic approach. By focusing on quality, supplier reliability, and competitive pricing, procurement managers can ensure they obtain high-grade 1-(4-Chlorophenyl)biguanide Hydrochloride (CAS 4022-81-5). Engaging directly with manufacturers and reputable suppliers from China provides an efficient pathway to secure this valuable compound for your research and development endeavors. If you are looking to buy high-purity 1-(4-Chlorophenyl)biguanide Hydrochloride, consider exploring partnerships with established chemical manufacturers who can offer consistent quality and dependable supply.