For professionals in the chemical and pharmaceutical industries, understanding the precise specifications and application potential of key reagents like Acetyl Chloride (CAS 75-36-5) is fundamental to successful synthesis and product development. As a critical acetylating agent, its quality directly influences reaction outcomes and the efficacy of end products.

Understanding Acetyl Chloride: The Basics

Acetyl Chloride, a derivative of acetic acid, is an acyl halide that presents as a clear, colorless, and fuming liquid. Its chemical formula, CH3COCl, hints at its high reactivity, primarily due to the electrophilic carbonyl carbon and the good leaving group ability of the chloride ion. This makes it an extremely effective agent for introducing acetyl groups (acetylation) into various organic molecules.

Critical Specifications for Buyers

When you purchase Acetyl Chloride, paying close attention to its specifications is paramount. Manufacturers typically provide detailed quality parameters:

  • Appearance: Clear, colorless fuming liquid.
  • Purity: Commonly specified as 99.0% or 99.9% by Gas Chromatography (GC). High purity is crucial for minimizing side reactions and ensuring the quality of synthesized compounds.
  • Boiling Point: Approximately 51°C, indicating its volatile nature.
  • Impurities: Limits are set for specific impurities, such as PCL3 (e.g., 100 ppm max), to ensure process compatibility.

These specifications are vital for anyone looking to buy Acetyl Chloride for industrial applications, especially in the pharmaceutical and agrochemical sectors where precision is key.

Diverse Applications Driven by Reactivity

The utility of Acetyl Chloride stems from its potent reactivity as an acetylation agent:

  • Pharmaceutical Industry: It is a fundamental building block for numerous drugs and intermediates. Its role in synthesizing compounds like acetylsalicylic acid, paracetamol, and ibuprofen highlights its importance in healthcare. It is also used in the production of various N-substituted acetamides and esters, which are common motifs in drug molecules.
  • Agrochemicals: Acetyl Chloride is an essential intermediate in the production of pesticides and herbicides, contributing to efficient crop protection and agricultural yields.
  • General Organic Synthesis: It serves as a versatile reagent for esterification, amidation, and Friedel-Crafts acylation reactions. These reactions are foundational in creating a wide range of organic compounds, from flavors and fragrances to polymers and specialty chemicals.

Partnering with a Reliable Acetyl Chloride Supplier

For companies seeking a consistent and high-quality supply, identifying a trustworthy acetyl chloride manufacturer is crucial. An established acetyl chloride supplier in China can offer competitive pricing while adhering to strict quality control standards. When inquiring about acetyl chloride price, always consider the comprehensive quality assurance and reliable supply chain offered by the supplier.

In summary, Acetyl Chloride’s specific properties and diverse applications make it an invaluable chemical intermediate. By focusing on precise specifications and sourcing from reputable manufacturers, businesses can leverage its full potential in their critical synthetic processes.