Fluorobromobenzene derivatives represent a class of highly functionalized aromatic compounds that are indispensable in modern organic synthesis. Their unique combination of halogen substituents provides chemists with versatile handles for a multitude of transformations, enabling the construction of complex molecular architectures. Among these valuable building blocks, 3,4-Dichloro-5-fluorobromobenzene (CAS 1000572-93-9) stands out for its specific substitution pattern and broad applicability. If you are looking to buy this compound, understanding its synthetic potential is key.

At NINGBO INNO PHARMCHEM CO.,LTD., we specialize in providing high-quality chemical intermediates, including a range of fluorinated aromatics. This article shines a light on the synthetic significance of fluorobromobenzene derivatives and highlights how you can procure essential compounds like 3,4-Dichloro-5-fluorobromobenzene.

The Versatility of Fluorobromobenzene Derivatives
The strategic placement of fluorine and bromine atoms on an aromatic ring creates molecules with enhanced reactivity and unique electronic properties. Bromine, being a good leaving group, is particularly amenable to palladium-catalyzed cross-coupling reactions such as Suzuki, Stille, Heck, and Sonogashira couplings. These reactions are foundational for carbon-carbon bond formation, a cornerstone of organic synthesis.

Fluorine, on the other hand, can significantly alter the physicochemical properties of a molecule, including its polarity, lipophilicity, metabolic stability, and binding interactions. Incorporating fluorine is a well-established strategy in drug discovery and agrochemical development to fine-tune the performance of active ingredients.

3,4-Dichloro-5-fluorobromobenzene: A Key Synthetic Intermediate
3,4-Dichloro-5-fluorobromobenzene, with CAS number 1000572-93-9 and molecular formula C6H2BrCl2F, exemplifies the utility of these derivatives. Its structure offers multiple points for chemical modification:

  • Bromine for Cross-Coupling: The bromine atom can readily participate in various palladium-catalyzed cross-coupling reactions to introduce aryl, vinyl, or alkynyl groups, expanding the carbon skeleton.
  • Chlorine and Fluorine Influence: The electron-withdrawing nature of the halogens can activate or deactivate certain positions on the ring for further electrophilic or nucleophilic aromatic substitution reactions. They also influence the overall electronic profile and potential interactions of synthesized molecules.
  • Building Block for Complex Structures: This compound serves as a valuable starting material for synthesizing pharmaceuticals, agrochemicals, and specialty materials that require precise halogen substitution patterns.

Sourcing High-Purity Compounds
For researchers and procurement managers, the ability to buy 3,4-Dichloro-5-fluorobromobenzene with guaranteed purity is essential. Impurities can complicate synthesis and compromise final product quality. NINGBO INNO PHARMCHEM CO.,LTD. is committed to being a reliable supplier, offering this compound with a typical assay of ≥97.0%. Our dedication to quality assurance ensures that your synthetic endeavors will be supported by reliable, high-performance chemical intermediates.

We invite you to inquire about the availability and pricing of 3,4-Dichloro-5-fluorobromobenzene. Partner with NINGBO INNO PHARMCHEM CO.,LTD. for your advanced chemistry needs and experience the advantage of quality sourcing. Contact us to learn more about how we can support your next project.