Methyl 2-(2-hydroxyphenyl)acetate, identified by CAS number 22446-37-3, is a significant organic compound that serves as a versatile building block across multiple industrial sectors. Its unique chemical structure and reactive functional groups make it a compound of interest for researchers and manufacturers alike, particularly in the agrochemical, pharmaceutical, and fragrance industries. This article explores its synthesis, key properties, and diverse applications.

The synthesis of Methyl 2-(2-hydroxyphenyl)acetate typically involves the esterification of 2-hydroxyphenylacetic acid with methanol. This process can be catalyzed by strong acids such as sulfuric acid or thionyl chloride. For example, reacting 2-hydroxyphenylacetic acid with a methanolic solution of hydrogen chloride, followed by standard work-up procedures, yields the desired methyl ester. Optimization of reaction conditions, including temperature, reaction time, and catalyst concentration, is crucial for achieving high purity and yield. Manufacturers often employ refined processes to ensure the product meets stringent specifications, such as a minimum purity of 98.0% and a white crystalline powder appearance.

Key properties of Methyl 2-(2-hydroxyphenyl)acetate include a melting point of 122-124°C and a boiling point of approximately 261.9°C at 760 mmHg. Its molecular formula C9H10O3 and molecular weight of 166.174 g/mol define its chemical identity. The presence of a phenolic hydroxyl group and a methyl ester moiety provides two distinct sites for further chemical modification, enabling its use in the synthesis of more complex molecules.

The applications of Methyl 2-(2-hydroxyphenyl)acetate are widespread and economically significant. Its most prominent use is as an intermediate in the production of azoxystrobin, a highly effective broad-spectrum fungicide crucial for modern agriculture. The demand from the agrochemical sector for this intermediate is substantial. Beyond agriculture, the compound's aromatic nature and ester functionality make it valuable in the fragrance industry, contributing specific aromatic characteristics to perfumes and colognes. In the pharmaceutical realm, it serves as a foundational component for synthesizing various active pharmaceutical ingredients (APIs) and drug candidates. Its utility also extends to research laboratories as a chemical reagent and analytical standard.

For businesses seeking to procure Methyl 2-(2-hydroxyphenyl)acetate, partnering with reliable manufacturers and suppliers is essential. NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated supplier committed to delivering high-quality chemical intermediates. We offer competitive pricing and ensure a consistent supply chain for our global B2B clientele. Whether you are involved in agrochemical production, fragrance formulation, or pharmaceutical research, we are equipped to meet your requirements. Contact us today to discuss your needs and receive a personalized quotation.