In the realm of organic chemistry, the precise synthesis and thorough understanding of chemical properties are foundational for any material's successful application. 2,4-Dichloro-3-fluoronitrobenzene (CAS 393-79-3) is a compound that exemplifies this principle, serving as a critical intermediate in various industrial processes. This article aims to shed light on its synthesis methodologies and its defining chemical characteristics, providing valuable information for chemists and product formulators seeking to purchase or utilize this compound.

Synthesis of 2,4-Dichloro-3-fluoronitrobenzene

The preparation of 2,4-Dichloro-3-fluoronitrobenzene typically involves the nitration of a precursor molecule. A common and efficient method described in chemical literature involves the nitration of 2,6-dichlorofluorobenzene. This process often utilizes a mixed acid system, comprising concentrated nitric acid and sulfuric acid, under controlled temperature conditions. For instance, a microchannel reactor system can be employed to manage the reaction's exothermicity and ensure high selectivity. The process involves introducing the reactants, such as 2,6-dichlorofluorobenzene dissolved in a solvent like dichloromethane, along with the mixed acid, into the reactor. Reaction parameters like temperature (e.g., 40°C), residence time, and reactant molar ratios are precisely controlled to maximize the yield and purity of the desired 2,4-Dichloro-3-fluoronitrobenzene. Post-reaction workup usually includes washing and drying steps to isolate the final product, often achieving purities of 97% or higher.

Key Chemical Properties and Specifications

  • Chemical Formula and Molecular Weight: C6H2Cl2FNO2, with a molecular weight of 209.99 g/mol.
  • Physical Appearance: Typically appears as a clear liquid or solid, depending on ambient temperature and purity. For example, its boiling point is approximately 279.3°C at 760 mmHg, and its flash point is around 122.7°C.
  • Density: Reported densities are around 1.622 g/cm³.
  • Purity: High purity levels, often specified as 97%min, are critical for its application in sensitive syntheses.
  • Stability: It is generally stable under normal temperatures and pressures, but proper storage in a cool, dry, well-ventilated area away from incompatible substances is recommended.
  • Solubility: As a substituted aromatic compound, it is expected to have good solubility in common organic solvents.

Procurement and Usage Considerations

For businesses looking to buy 2,4-Dichloro-3-fluoronitrobenzene, understanding these properties is crucial for selecting appropriate storage, handling, and reaction conditions. When sourcing this intermediate, it is advisable to partner with reliable manufacturers and suppliers who can provide detailed specifications and ensure consistent product quality. The ability to obtain this chemical at a competitive price, especially in bulk quantities from Chinese manufacturers, can significantly impact the cost-effectiveness of downstream production processes.

As a leading supplier of fine chemical intermediates, we are dedicated to providing high-quality 2,4-Dichloro-3-fluoronitrobenzene that meets rigorous industry standards. Our commitment extends to ensuring that our clients have access to comprehensive technical data and reliable sourcing channels. If you are researching synthesis routes or need to buy this essential intermediate, our team is ready to assist you with your inquiries and provide tailored solutions.