For chemists and process engineers, understanding the synthesis and intrinsic chemical properties of key intermediates is fundamental to successful product development and manufacturing. Mono-6-O-(p-toluenesulfonyl)-beta-cyclodextrin (CAS 67217-55-4) is one such compound, with a well-defined synthesis pathway and notable chemical characteristics that make it valuable across various industries. As a producer and supplier of fine chemicals, we offer insights into these aspects for our B2B clientele.

The synthesis of Mono-6-O-(p-toluenesulfonyl)-beta-cyclodextrin typically involves the selective tosylation of beta-cyclodextrin. A common and effective method uses 1-(p-toluenesulfonyl)imidazole as the tosylating agent, reacting with beta-cyclodextrin under specific conditions, often in an aqueous medium with controlled pH adjustments using sodium hydroxide. This process aims for regioselective substitution at the primary hydroxyl group (C6) of the cyclodextrin ring. While various synthetic routes exist, our manufacturing processes are optimized to achieve high yields and purity, ensuring that the product's integrity is maintained.

The resulting Mono-6-O-(p-toluenesulfonyl)-beta-cyclodextrin possesses a molecular weight of 1289.17 g/mol and a distinct chemical formula of C49H76O37S. Key chemical properties include its solubility: it is soluble in polar aprotic solvents like DMF and DMSO but generally insoluble in water and less polar solvents such as methanol and chloroform. Its solid form is typically a white powder or crystals. The presence of the tosyl group imparts specific reactivity and complexation capabilities, differentiating it from native beta-cyclodextrin and enabling its use in applications requiring enhanced hydrophobicity or specific molecular interactions.

For procurement managers looking to buy this compound, understanding these synthesis and property details helps in evaluating potential suppliers. As a manufacturer, we prioritize efficient synthesis and stringent quality control to deliver a product that consistently meets specifications. If your R&D or production requires this specialty chemical, we encourage you to leverage our expertise as a reliable supplier. Contact us for detailed specifications and bulk pricing, ensuring you receive a high-quality intermediate for your chemical synthesis needs.