The Synthesis of Ibrutinib: The Crucial Role of Acryloyl Chloride in Pharma Manufacturing
The synthesis of complex pharmaceutical compounds often hinges on the availability and precise application of specific chemical intermediates. Among these, acryloyl chloride (CAS: 814-68-6) emerges as a particularly crucial element, especially in the manufacturing of Ibrutinib, a groundbreaking drug used in the treatment of certain cancers.
Ibrutinib, chemically known as 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one, relies on acryloyl chloride for a key acylation step in its multi-stage synthesis. This reaction involves introducing the acryloyl group onto a precursor molecule, a transformation that acryloyl chloride, with its highly reactive acid chloride functionality, excels at. The successful and efficient synthesis of Ibrutinib is therefore directly influenced by the quality and reliable supply of acryloyl chloride.
The industrial synthesis of acryloyl chloride typically involves the chlorination of acrylic acid. This process yields a colorless liquid with a molecular weight of 90.51 g/mol and a specific gravity around 1.11 g/cm³. While its reactivity is a significant advantage for chemical synthesis, it also means that acryloyl chloride is a hazardous substance, being both toxic and a lachrymator. Consequently, stringent safety protocols are essential during its production, storage, and use in pharmaceutical manufacturing facilities. This includes specialized handling equipment and rigorous adherence to safety guidelines to protect workers.
As a key intermediate for Ibrutinib, understanding the supply chain and manufacturing processes for acryloyl chloride is vital for pharmaceutical companies. Sourcing high-purity acryloyl chloride from reputable manufacturers ensures the consistency and efficacy of the final drug product. The meticulous control over reaction conditions and purification processes for both acryloyl chloride and the subsequent Ibrutinib synthesis is paramount to achieving therapeutic success and meeting regulatory standards. The journey from basic chemicals like acrylic acid to life-saving drugs like Ibrutinib showcases the sophisticated and critical role of chemical intermediates.
Ibrutinib, chemically known as 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one, relies on acryloyl chloride for a key acylation step in its multi-stage synthesis. This reaction involves introducing the acryloyl group onto a precursor molecule, a transformation that acryloyl chloride, with its highly reactive acid chloride functionality, excels at. The successful and efficient synthesis of Ibrutinib is therefore directly influenced by the quality and reliable supply of acryloyl chloride.
The industrial synthesis of acryloyl chloride typically involves the chlorination of acrylic acid. This process yields a colorless liquid with a molecular weight of 90.51 g/mol and a specific gravity around 1.11 g/cm³. While its reactivity is a significant advantage for chemical synthesis, it also means that acryloyl chloride is a hazardous substance, being both toxic and a lachrymator. Consequently, stringent safety protocols are essential during its production, storage, and use in pharmaceutical manufacturing facilities. This includes specialized handling equipment and rigorous adherence to safety guidelines to protect workers.
As a key intermediate for Ibrutinib, understanding the supply chain and manufacturing processes for acryloyl chloride is vital for pharmaceutical companies. Sourcing high-purity acryloyl chloride from reputable manufacturers ensures the consistency and efficacy of the final drug product. The meticulous control over reaction conditions and purification processes for both acryloyl chloride and the subsequent Ibrutinib synthesis is paramount to achieving therapeutic success and meeting regulatory standards. The journey from basic chemicals like acrylic acid to life-saving drugs like Ibrutinib showcases the sophisticated and critical role of chemical intermediates.
Perspectives & Insights
Silicon Analyst 88
“This includes specialized handling equipment and rigorous adherence to safety guidelines to protect workers.”
Quantum Seeker Pro
“As a key intermediate for Ibrutinib, understanding the supply chain and manufacturing processes for acryloyl chloride is vital for pharmaceutical companies.”
Bio Reader 7
“Sourcing high-purity acryloyl chloride from reputable manufacturers ensures the consistency and efficacy of the final drug product.”