1-(Difluoromethoxy)-3-nitrobenzene is a compound of significant interest in organic chemistry due to its versatile applications as an intermediate. Its synthesis and well-defined properties make it a valuable asset for researchers and manufacturers alike. Understanding these aspects is crucial for leveraging its full potential.

The synthesis of 1-(Difluoromethoxy)-3-nitrobenzene can be achieved through several routes, often involving the introduction of the difluoromethoxy group onto a nitrobenzene precursor. Common methods include reactions with difluoromethylating agents, frequently utilizing phase-transfer catalysts in alkaline media. Industrial production often favors water-phase synthesis for its environmental benefits and reduced solvent recovery requirements. Alternative methodologies, such as those employing diethylaminosulfur trifluoride (DAST), offer high yields but necessitate strict temperature control.

The compound's physical and chemical properties are well-characterized. It typically appears as a light yellow transparent liquid, with a density of around 1.391 g/mL and a boiling point between 240-242°C. Spectroscopic analysis, including NMR, IR, and mass spectrometry, provides detailed insights into its molecular structure and purity, confirming the presence of characteristic functional groups. The difluoromethoxy group, with its specific coupling patterns in NMR spectra, serves as a diagnostic fingerprint.

The electronic structure analysis of 1-(Difluoromethoxy)-3-nitrobenzene reveals the interplay of electron-withdrawing substituents, which influences its chemical reactivity. This understanding is vital for its application in further synthetic steps. For professionals seeking to buy or inquire about the price of this compound, detailed technical specifications are often available from manufacturers, ensuring the suitability of the material for specific synthetic needs. Reliable sourcing of such intermediates is key to successful research and production.