The Synthesis and Properties of Cyclobutanecarboxylic Acid (CAS 3721-95-7)
Cyclobutanecarboxylic acid, cataloged under CAS number 3721-95-7, is a foundational organic intermediate recognized for its unique four-membered ring structure and its utility in a broad spectrum of chemical syntheses. Understanding its synthesis and inherent properties is key to unlocking its full potential in research and industrial applications.
The preparation of Cyclobutanecarboxylic acid typically involves well-established chemical methodologies. One common route is the decarboxylation of 1,1-cyclobutanedicarboxylic acid, often achieved through thermal treatment. Another significant synthesis pathway involves the oxidative ring contraction of cyclopentanone, catalyzed by selenium dioxide. These methods ensure the production of a chemical that is stable and reliable for various applications.
Chemically, Cyclobutanecarboxylic acid presents itself as a colorless to light yellow liquid. Its melting point is approximately -7.5°C, and it boils at around 195°C. The compound exhibits slight solubility in water but is readily soluble in many organic solvents, such as chloroform and methanol. Its pKa value of 4.785 at 25°C indicates its acidic nature, which is typical for carboxylic acids. These properties collectively define its behavior in chemical reactions and its suitability as an organic intermediate.
As a critical chemical building block, Cyclobutanecarboxylic acid serves as a precursor for numerous monosubstituted cyclobutane derivatives. These derivatives are valuable in the synthesis of complex molecules, particularly within the pharmaceutical industry, where they form the backbone of many active pharmaceutical ingredients (APIs). The ability to precisely control the synthesis and derivatization of Cyclobutanecarboxylic acid is central to achieving targeted molecular structures.
NINGBO INNO PHARMCHEM CO.,LTD., a prominent manufacturer in China, specializes in the production of high-purity Cyclobutanecarboxylic acid. We are committed to providing researchers and industrial clients with a reliable supply of this essential organic intermediate, ensuring consistent quality and performance. Whether for pharmaceutical synthesis building block requirements or other specialized chemical uses, our product is designed to meet the highest standards.
The preparation of Cyclobutanecarboxylic acid typically involves well-established chemical methodologies. One common route is the decarboxylation of 1,1-cyclobutanedicarboxylic acid, often achieved through thermal treatment. Another significant synthesis pathway involves the oxidative ring contraction of cyclopentanone, catalyzed by selenium dioxide. These methods ensure the production of a chemical that is stable and reliable for various applications.
Chemically, Cyclobutanecarboxylic acid presents itself as a colorless to light yellow liquid. Its melting point is approximately -7.5°C, and it boils at around 195°C. The compound exhibits slight solubility in water but is readily soluble in many organic solvents, such as chloroform and methanol. Its pKa value of 4.785 at 25°C indicates its acidic nature, which is typical for carboxylic acids. These properties collectively define its behavior in chemical reactions and its suitability as an organic intermediate.
As a critical chemical building block, Cyclobutanecarboxylic acid serves as a precursor for numerous monosubstituted cyclobutane derivatives. These derivatives are valuable in the synthesis of complex molecules, particularly within the pharmaceutical industry, where they form the backbone of many active pharmaceutical ingredients (APIs). The ability to precisely control the synthesis and derivatization of Cyclobutanecarboxylic acid is central to achieving targeted molecular structures.
NINGBO INNO PHARMCHEM CO.,LTD., a prominent manufacturer in China, specializes in the production of high-purity Cyclobutanecarboxylic acid. We are committed to providing researchers and industrial clients with a reliable supply of this essential organic intermediate, ensuring consistent quality and performance. Whether for pharmaceutical synthesis building block requirements or other specialized chemical uses, our product is designed to meet the highest standards.
Perspectives & Insights
Core Pioneer 24
“The compound exhibits slight solubility in water but is readily soluble in many organic solvents, such as chloroform and methanol.”
Silicon Explorer X
“These properties collectively define its behavior in chemical reactions and its suitability as an organic intermediate.”
Quantum Catalyst AI
“As a critical chemical building block, Cyclobutanecarboxylic acid serves as a precursor for numerous monosubstituted cyclobutane derivatives.”