For chemists and material scientists, a thorough understanding of a compound's physical and chemical properties is fundamental to its effective utilization. 1,3-Difluoro-5-nitrobenzene (CAS 2265-94-3) is a chemical intermediate that merits such detailed examination due to its significant role in advanced synthesis. This article delves into the technical aspects of this compound, offering insights from the perspective of a dedicated manufacturer and supplier, NINGBO INNO PHARMCHEM.

Physically, 1,3-Difluoro-5-nitrobenzene is typically observed as a light yellow liquid. Key physical parameters include a density of approximately 1.407 g/cm³, a relatively low melting point around 17°C, and a boiling point of 176-177°C at atmospheric pressure. These properties are critical for handling, storage, and process design. The refractive index is also a noteworthy characteristic, often around 1.499, providing another identifier for purity verification.

Chemically, the presence of two fluorine atoms and a nitro group on the benzene ring dictates its reactivity. The electron-withdrawing nature of these substituents influences the aromatic ring's susceptibility to various reactions. While the nitro group deactivates the ring towards electrophilic substitution, it activates it for nucleophilic aromatic substitution, making it a valuable precursor for compounds where such reactions are desired. The fluorine atoms can also influence solubility and stability, crucial factors for formulation and application.

The synthesis of 1,3-Difluoro-5-nitrobenzene generally involves nitration of a difluorobenzene precursor under controlled conditions. Achieving high purity, such as the ≥99.0% assay we guarantee, requires careful selection of raw materials, precise control over reaction parameters like temperature and reagent addition, and efficient purification techniques such as distillation or chromatography. As a manufacturer, optimizing these synthesis routes is key to providing a reliable and cost-effective product for industries that buy this chemical.

The primary applications for this compound lie in its role as an intermediate for pharmaceuticals and agrochemicals. Its structure allows for the introduction of diverse functional groups, paving the way for the creation of complex molecules with desired biological activities. For companies seeking to purchase this high-purity intermediate, understanding these technical specifications and the synthesis process underscores the value offered by experienced suppliers like NINGBO INNO PHARMCHEM. We encourage you to contact us for detailed specifications and to request a quote for your synthesis needs.