Bromoacetyl bromide (CAS 598-21-0) is a chemical reagent whose effective utilization hinges on a thorough understanding of its properties and the necessary precautions for handling. For R&D scientists and procurement managers in the chemical and pharmaceutical industries, grasping these technical details is paramount for ensuring safety, optimizing reaction outcomes, and facilitating efficient purchasing decisions.

From a physical standpoint, Bromoacetyl bromide is typically encountered as a liquid, often appearing as colorless to a faint yellow hue. Its molecular formula is C2H2Br2O, with a molecular weight of 201.84 g/mol. Key physical properties include a density of approximately 2.317 g/mL at 25°C and a boiling point of around 148.5 °C at atmospheric pressure. Its reactivity means it can be sensitive to moisture, undergoing hydrolysis, so storage under dry, inert conditions is recommended. The compound's corrosive nature is a critical characteristic that dictates stringent safety protocols during handling and storage.

Chemically, Bromoacetyl bromide is a potent electrophile and acylating agent. The presence of the highly electronegative bromine atom adjacent to the carbonyl group makes the alpha-carbon susceptible to nucleophilic attack. This property is fundamental to its role in numerous organic transformations, including acylation of alcohols and amines, and as a precursor in the synthesis of heterocycles and complex organic frameworks. Its high reactivity, while beneficial for synthesis, also implies the need for careful control of reaction conditions to prevent unwanted side reactions or decomposition.

For procurement professionals, understanding the typical purity levels offered by manufacturers is important. Bromoacetyl bromide is commonly available with purities of 98% or higher, which is crucial for applications demanding precision, such as in pharmaceutical intermediate synthesis. When requesting quotations, specifying the required purity and quantity is essential. Always demand a Certificate of Analysis (COA) with each batch to verify these specifications.

Safety is a primary concern when working with Bromoacetyl bromide. As a corrosive substance (Hazard Symbol: Corrosive C, Risk Code: 34), it can cause severe skin burns and eye damage. Appropriate personal protective equipment (PPE) is non-negotiable, including chemical-resistant gloves, safety goggles, face shields, and lab coats. Work should always be conducted in a well-ventilated fume hood. Understanding the transport information, such as UN 2513, Hazard Class 8, and Packing Group II, is also vital for logistics and compliance.

By familiarizing yourself with these technical aspects, chemists and procurement specialists can make informed decisions when purchasing and utilizing Bromoacetyl bromide, ensuring both operational efficiency and safety in your chemical operations. For those looking to buy this crucial reagent, engaging with a reputable manufacturer that provides comprehensive technical documentation and support is highly recommended.