Understanding the detailed chemical profile of an intermediate is fundamental for its effective utilization in synthesis. 3-Fluoro-4-nitroaniline, identified by CAS 2369-13-3, is characterized by a specific combination of functional groups that dictate its physical properties and chemical reactivity. NINGBO INNO PHARMCHEM CO.,LTD. offers this compound and provides insights into its chemical behavior, aiding chemists in its optimal application.

Physically, 3-Fluoro-4-nitroaniline typically presents as a light yellow to brown crystalline powder. Its melting point is generally reported in the range of 152-157 °C, indicating a stable solid form under standard laboratory conditions. The molecular formula is C6H5FN2O2, and its molecular weight is approximately 156.11 g/mol. The presence of the fluorine atom influences electron distribution within the benzene ring, affecting its reactivity. The nitro group is strongly electron-withdrawing, while the amino group is electron-donating. This interplay of electronic effects makes the molecule amenable to various electrophilic and nucleophilic substitution reactions.

The reactivity of 3-Fluoro-4-nitroaniline is primarily governed by its amino and nitro functionalities, as well as the activating or deactivating effects of the fluorine substituent. The amino group can undergo typical reactions such as acylation, alkylation, and diazotization. Diazotization, for instance, converts the amino group into a diazonium salt, which is a highly versatile intermediate for introducing various substituents onto the aromatic ring, including halogens, cyano groups, or hydroxyl groups. The presence of the nitro group, being a deactivating group, influences the position of further electrophilic aromatic substitution, typically directing incoming electrophiles to positions meta to itself, though the activating amino group often dominates.

The fluorine atom, while generally considered a weak deactivator in electrophilic aromatic substitution, can influence regioselectivity due to its inductive electron-withdrawing effect. In nucleophilic aromatic substitution, fluorine can act as a leaving group under specific conditions, especially when activated by strongly electron-withdrawing groups like a nitro group at the para position. Therefore, reactions involving 3-Fluoro-4-nitroaniline need careful consideration of these substituent effects to predict and control the reaction outcomes.

The synthesis of other halogenated organic benzenes, such as 2,4-Difluoronitrobenzene or 2-Fluoro-4-iodo-1-nitrobenzene, highlights the compound's utility as a precursor. These transformations often involve specific reaction sequences that exploit the reactivity of the amino group and the influence of the fluorine and nitro substituents. The ability to reliably perform these conversions underscores the importance of the foundational chemical properties of 3-Fluoro-4-nitroaniline.

In conclusion, the chemical profile of 3-Fluoro-4-nitroaniline is rich with possibilities for synthetic chemists. Its distinct physical properties and predictable reactivity patterns make it an invaluable intermediate for developing a wide array of complex organic molecules. NINGBO INNO PHARMCHEM CO.,LTD. provides access to this compound, enabling chemists to explore and leverage its chemical potential.