Understanding the fundamental chemical properties of intermediates is crucial for their effective utilization in synthesis. 3-Fluoro-4-nitrobenzonitrile, identified by CAS number 218632-01-0, is a compound that merits close examination due to its versatile reactivity and application potential. As a derivative of benzonitrile, it integrates a unique combination of functional groups that unlock diverse synthetic pathways. Let's delve into its chemical profile and explore its significance.

At its core, 3-Fluoro-4-nitrobenzonitrile (C7H3FN2O2) is a molecule characterized by a benzene ring substituted with a nitrile group (-CN), a fluorine atom (-F), and a nitro group (-NO2). The specific arrangement – fluorine at position 3 and the nitro group at position 4 relative to the nitrile group – dictates its electron distribution and reactivity. This particular configuration is key to its utility as an intermediate in organic synthesis.

Physically, 3-Fluoro-4-nitrobenzonitrile is typically presented as a solid, often described as a white to light yellow powder. Its molecular weight is approximately 166.11 g/mol. Key physical properties often cited include a melting point in the range of 72-73°C, indicating its solid state at room temperature. Other measured properties, such as density (around 1.4 g/cm³) and boiling point (approximately 316.4°C at 760 mmHg), provide further insights into its handling and behavior under various conditions. These parameters are vital for process engineers and chemists when designing reaction conditions and storage protocols.

The chemical reactivity of 3-Fluoro-4-nitrobenzonitrile stems from its functional groups. The nitro group is electron-withdrawing, influencing the aromatic ring's susceptibility to nucleophilic attack. The nitrile group can undergo various transformations, such as hydrolysis to carboxylic acids or reduction to amines. The fluorine atom, a highly electronegative element, can activate adjacent positions for substitution reactions or influence the overall electronic properties of molecules synthesized from it.

As an intermediate, its applications are predominantly in the synthesis of more complex organic molecules. It serves as a critical building block in the pharmaceutical industry for creating novel drug compounds, particularly those requiring fluorinated aromatic structures. In the agrochemical sector, it contributes to the development of advanced pesticides and herbicides. Furthermore, its utility extends to the creation of specialty chemicals and advanced materials where specific electronic or physical properties are desired.

For businesses looking to procure this compound, understanding these chemical properties is essential. When searching for a supplier, verifying the assay (purity level, e.g., ≥98.0%) and ensuring consistent physical characteristics are paramount. The ability of a manufacturer to provide reliable data and consistent quality makes them a valuable partner for companies engaged in chemical synthesis. If you are seeking a dependable source for 3-Fluoro-4-nitrobenzonitrile, consider partnering with experienced chemical manufacturers who can guarantee these critical specifications for your production needs.