Understanding the detailed chemical profile of reagents is fundamental to their successful application in scientific research and industrial processes. N-ethynyl-N,4-dimethylbenzenesulfonamide, also known as Zhao's coupling reagent, is a notable amide compound with significant utility in organic synthesis. NINGBO INNO PHARMCHEM CO.,LTD. provides this compound with comprehensive chemical information to ensure clarity and facilitate its effective use.

At its core, N-ethynyl-N,4-dimethylbenzenesulfonamide is characterized by its unique structure, which combines an ethynyl group with a tosylamide moiety. This combination imparts specific reactivity that is leveraged in various chemical transformations. The compound typically presents as a white to off-white solid, with a reported melting point between 75-76 °C. These physical properties, along with its high purity (often ≥97.0%), make it a manageable and reliable reagent for complex syntheses. Researchers often seek to buy Zhao's coupling reagent because of these predictable characteristics.

As an amide compound, N-ethynyl-N,4-dimethylbenzenesulfonamide participates in reactions characteristic of this functional group, but its ethynyl substituent also confers distinct reactivity. This dual nature makes it a versatile tool, particularly in coupling reactions where it activates carboxylic acids for amide bond formation. The N-Methyl-N-p-toluenesulfonyl ethynylamine properties are therefore crucial for chemists designing synthetic routes. Sourcing CAS 1005500-75-3 from reputable suppliers like NINGBO INNO PHARMCHEM CO.,LTD. ensures access to a compound with a well-documented chemical profile and consistent quality.

The significance of this amide compound extends to its role as an intermediate in the synthesis of various fine chemicals and pharmaceutical precursors. Its ability to facilitate efficient bond formation without significant racemization makes it particularly valuable in the synthesis of chiral molecules. The exploration of N-ethynyl-N,4-dimethylbenzenesulfonamide uses continues to reveal its broad applicability across different branches of chemistry, from medicinal chemistry to material science.

In summary, N-ethynyl-N,4-dimethylbenzenesulfonamide is a key amide compound with a distinct chemical profile that underpins its utility in organic synthesis. Its physical properties, reactivity, and high purity make it an indispensable reagent for researchers and manufacturers. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing this essential chemical, supporting advancements in the field of chemistry.