Understanding the fundamental chemistry of specialized compounds is key to unlocking their full potential in research and industrial applications. 18-Crown-6 (CAS 17455-13-9), a member of the crown ether family, is a fascinating molecule with a distinct chemical profile that makes it indispensable in various synthesis pathways and analytical techniques.

Chemically, 18-Crown-6 is a cyclic polyether with the molecular formula C12H24O6. Its structure consists of a ring of six ethylene glycol units, forming a 18-membered ring with six oxygen atoms strategically positioned to coordinate with cations. The cavity size of 18-Crown-6 is approximately 130-150 pm, which makes it exceptionally selective for binding potassium ions (K+), whose ionic radius is around 138 pm. This precise fit allows for the formation of stable, neutral complexes with these cations.

This cation-binding capability is the bedrock of its utility as a phase-transfer catalyst (PTC). In reactions involving immiscible phases, such as an aqueous solution of a salt and an organic solvent, 18-Crown-6 can chelate the cation of the salt. The resulting lipophilic ion-pair then becomes soluble in the organic phase, effectively transferring the anion (which is often the reactive species) into the organic medium. This dramatically accelerates reaction rates, allows for lower reaction temperatures, and often improves yields and selectivity in processes like alkylations, esterifications, and nucleophilic substitutions.

Beyond its role as a PTC, the complexing ability of 18-Crown-6 makes it valuable in chemical analysis for the separation and enrichment of metal ions, particularly alkali metals. It is also used in the development of ion-selective electrodes and in other areas of materials science where controlled cation transport is required.

The synthesis applications are broad. For example, in the preparation of ethers via Williamson ether synthesis, using potassium hydroxide as the base in a biphasic system is significantly enhanced by the presence of 18-Crown-6. It effectively solubilizes the hydroxide ion in the organic phase, enabling it to react efficiently with the alkyl halide. Similarly, in the synthesis of nitriles from alkyl halides using potassium cyanide, 18-Crown-6 acts as an essential mediator.

For researchers and industrial chemists, sourcing high-purity 18-Crown-6 is crucial for reliable and reproducible synthesis results. As a leading manufacturer in China, we are dedicated to providing 18-Crown-6 that meets stringent quality specifications. When you choose to buy 18-crown-6 from us, you are assured of a product that upholds the chemical principles that make it so valuable.

We offer competitive 18-crown-6 price options and are a trusted 18-crown-6 supplier in China. By understanding the chemistry and the sourcing implications, you can make informed decisions. We invite you to explore our offerings and experience the quality and reliability that our 18-Crown-6 provides for your synthesis needs.