Understanding the fundamental chemistry of key reagents is paramount for any chemist aiming for successful synthesis. (tert-Butyldimethylsilyl)acetylene, CAS 86318-61-8, is a molecule that consistently proves its versatility and importance across various chemical disciplines. This organosilicon compound, characterized by its clear liquid appearance, combines the reactivity of an alkyne with the stabilizing and protective features of a tert-butyldimethylsilyl group.

At its core, the molecule’s formula is C8H16Si, with a molecular weight of approximately 140.3 g/mol. Its physical properties, such as a boiling point around 116-117 °C and a density of 0.751 g/mL, indicate it is a relatively volatile organic compound, requiring appropriate handling and storage conditions, typically under inert gas and protected from moisture due to its sensitivity. The tert-butyldimethylsilyl (TBS) group is a bulky, lipophilic protecting group that renders the terminal alkyne less reactive towards certain reagents, while also enhancing solubility in non-polar organic solvents.

The primary utility of (tert-Butyldimethylsilyl)acetylene stems from two key roles: as a versatile building block in carbon-carbon bond formation and as a protective group for terminal alkynes. In synthesis, the terminal alkyne can undergo a plethora of reactions including metal-catalyzed cross-couplings (e.g., Sonogashira coupling), nucleophilic additions, and cycloadditions. The TBS group can be selectively removed using reagents like tetra-n-butylammonium fluoride (TBAF) or under mild basic conditions, regenerating the free alkyne for further functionalization. This makes it invaluable in multi-step synthesis, particularly in the pharmaceutical industry where precise control over functional group reactivity is critical.

Beyond its synthetic applications, its role in silicon chemistry, contributing to the synthesis of silanes and siloxanes, is significant for industries ranging from electronics to materials science. For professionals looking to buy this compound, it's crucial to source from a reliable manufacturer that guarantees purity and consistency. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality (tert-Butyldimethylsilyl)acetylene, supporting your research and development endeavors with a product that meets stringent specifications.

We encourage chemists and procurement specialists to inquire about our product. Understanding the chemistry of (tert-Butyldimethylsilyl)acetylene empowers informed decisions, and we are here to be your trusted supplier for this essential chemical intermediate.