1,1,3,3-Tetramethoxypropane, known by its CAS number 102-52-3, is a fascinating molecule within the realm of organic chemistry. As an acetal, it possesses unique reactive properties that make it a valuable commodity in the fine chemical industry. This article explores its fundamental chemistry, key properties, and the synthesis processes that bring this important intermediate to market.

At its core, 1,1,3,3-Tetramethoxypropane is derived from malonaldehyde, a simple dialdehyde. In its tetramethoxypropane form, the aldehyde groups are protected as dimethyl acetals. This acetal protection is a common strategy in organic synthesis, rendering the carbonyl functionalities less reactive under certain conditions while allowing for facile deprotection when needed. The molecular formula C7H16O4 and a molecular weight of approximately 164.20 g/mol characterize its composition. Its structure can be represented as CH3O-CH(CH2)-CH(OCH3)2, illustrating the two acetal groups flanking a central methylene group.

Understanding the physical and chemical properties of 1,1,3,3-Tetramethoxypropane is vital for its effective use and handling. It typically presents as a clear, colorless to yellow-brown liquid. Its boiling point is around 183 °C at standard atmospheric pressure, though it can also be distilled at lower temperatures under vacuum (e.g., 70-75 °C at 15 mmHg). Its density is close to 0.964 g/cm³ at 25 °C. While it is immiscible with water, it shows solubility in common organic solvents such as chloroform and ethyl acetate. Importantly, this compound is sensitive to moisture, necessitating storage under inert gas and protection from humidity to maintain its integrity. It is also classified as combustible, with a flash point around 54.4 °C.

The synthesis of 1,1,3,3-Tetramethoxypropane typically involves the acetalization of malonaldehyde or its precursors with methanol in the presence of an acid catalyst. For instance, reacting malonaldehyde bis(diethyl acetal) with methanol or directly reacting malonaldehyde with methanol under acidic conditions can yield the desired product. Industrial production often focuses on optimizing these reactions for yield, purity, and cost-effectiveness. Manufacturers strive to achieve high assay values, typically ≧98%, to meet the demands of downstream applications.

The significance of 1,1,3,3-Tetramethoxypropane lies in its subsequent reactions. Upon deprotection, it liberates malonaldehyde, a reactive species that can participate in a variety of condensation and cyclization reactions. This makes it an indispensable building block for synthesizing heterocyclic compounds, which are prevalent in pharmaceuticals and dyestuffs. For businesses looking to buy this chemical, understanding its reactivity profile is key to unlocking its full potential in their specific synthesis projects.

As a leading manufacturer and supplier of fine chemical intermediates, our focus is on delivering 1,1,3,3-Tetramethoxypropane that meets the highest standards of purity and consistency. We leverage optimized synthesis routes and stringent quality control measures to ensure that our product reliably serves the complex needs of our clients in the pharmaceutical, dye, and agricultural sectors. Inquire with us to learn more about its specifications and how it can benefit your production processes.