The Chemistry of 4-Amino-2-chloro-3-fluorobenzonitrile: Synthesis and Applications
Understanding the chemical properties and synthesis routes of key intermediates is fundamental to progress in various scientific fields. 4-Amino-2-chloro-3-fluorobenzonitrile (CAS: 757247-99-7) is a prime example of such a compound, celebrated for its utility as an organic synthesis building block. This article delves into its chemical characteristics and the diverse applications it enables.
The synthesis of 4-Amino-2-chloro-3-fluorobenzonitrile typically involves precursors such as 4-amino-2-chloro-3-fluorobenzaldehyde or 3-chloro-2-fluoroaniline. Through established chemical methodologies, these raw materials are transformed into the desired product, ensuring high yields and purity levels, often exceeding 97%. The resulting compound presents as a solid, commonly gray to light gray in appearance, with key physical properties like a boiling point of 320°C and a density of 1.42.
The molecular formula, C7H4ClFN2, and a molecular weight of 170.57, hint at the compound's rich chemical functionality. The presence of an amino group (-NH2), a nitrile group (-CN), and halogen substituents (chlorine and fluorine) on the benzene ring makes it an extremely versatile molecule for further chemical modifications. This versatility is precisely why it's so valuable as an organic synthesis building block.
In the realm of organic chemistry, 4-Amino-2-chloro-3-fluorobenzonitrile is employed in the construction of complex molecular architectures. It serves as a critical component in the development of new pharmaceuticals, agrochemicals, and advanced materials. Its ability to participate in a wide array of reactions, such as nucleophilic aromatic substitution, diazotization, and coupling reactions, underscores its importance.
For researchers seeking to buy this essential intermediate, sourcing from reputable manufacturers, particularly in China, is a common practice. These suppliers often provide comprehensive technical data, including synthesis pathways and purity reports, ensuring that the material meets the demanding standards of scientific research and industrial application.
The synthesis of 4-Amino-2-chloro-3-fluorobenzonitrile typically involves precursors such as 4-amino-2-chloro-3-fluorobenzaldehyde or 3-chloro-2-fluoroaniline. Through established chemical methodologies, these raw materials are transformed into the desired product, ensuring high yields and purity levels, often exceeding 97%. The resulting compound presents as a solid, commonly gray to light gray in appearance, with key physical properties like a boiling point of 320°C and a density of 1.42.
The molecular formula, C7H4ClFN2, and a molecular weight of 170.57, hint at the compound's rich chemical functionality. The presence of an amino group (-NH2), a nitrile group (-CN), and halogen substituents (chlorine and fluorine) on the benzene ring makes it an extremely versatile molecule for further chemical modifications. This versatility is precisely why it's so valuable as an organic synthesis building block.
In the realm of organic chemistry, 4-Amino-2-chloro-3-fluorobenzonitrile is employed in the construction of complex molecular architectures. It serves as a critical component in the development of new pharmaceuticals, agrochemicals, and advanced materials. Its ability to participate in a wide array of reactions, such as nucleophilic aromatic substitution, diazotization, and coupling reactions, underscores its importance.
For researchers seeking to buy this essential intermediate, sourcing from reputable manufacturers, particularly in China, is a common practice. These suppliers often provide comprehensive technical data, including synthesis pathways and purity reports, ensuring that the material meets the demanding standards of scientific research and industrial application.
Perspectives & Insights
Alpha Spark Labs
“The resulting compound presents as a solid, commonly gray to light gray in appearance, with key physical properties like a boiling point of 320°C and a density of 1.”
Future Pioneer 88
“The presence of an amino group (-NH2), a nitrile group (-CN), and halogen substituents (chlorine and fluorine) on the benzene ring makes it an extremely versatile molecule for further chemical modifications.”
Core Explorer Pro
“This versatility is precisely why it's so valuable as an organic synthesis building block.”