4-Bromophenyl Isothiocyanate (CAS 1985-12-2) is a fascinating organic compound with significant utility in various chemical disciplines. Its molecular structure, featuring both a reactive isothiocyanate group (-NCS) and a bromine atom on an aromatic ring, endows it with a rich chemistry that is exploited in numerous synthetic pathways.

The synthesis of 4-Bromophenyl Isothiocyanate often involves the reaction of 4-bromoaniline with thiophosgene or related reagents. However, alternative, often safer, methods are also employed by experienced manufacturers. These methods are critical for producing the compound with high purity, typically around 98%, which is essential for its downstream applications. As a manufacturer in China, we leverage optimized synthetic routes to ensure consistent quality and yield for our clients.

One of the primary applications of 4-Bromophenyl Isothiocyanate is as a versatile building block in organic synthesis. The isothiocyanate group readily undergoes addition reactions with nucleophiles such as amines, alcohols, and thiols, leading to the formation of thioureas, thiocarbamates, and dithiocarbamates, respectively. These derivatives can serve as precursors to a wide range of heterocyclic compounds, many of which possess important biological activities.

Furthermore, the bromine atom on the phenyl ring provides an additional handle for further chemical modification. It can participate in palladium-catalyzed cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings, allowing for the introduction of diverse substituents and the construction of more complex molecular architectures. This makes 4-Bromophenyl Isothiocyanate invaluable for creating novel organic molecules for research and development.

Beyond general organic synthesis, 4-Bromophenyl Isothiocyanate finds specific use as an intermediate in the production of Active Pharmaceutical Ingredients (APIs). Its ability to form key structural motifs within drug molecules makes it a sought-after commodity for pharmaceutical companies. When looking to buy this compound, partnering with a reliable supplier that guarantees high purity and offers competitive pricing is crucial for project success. We, as a dedicated supplier and manufacturer in China, are committed to meeting these demands.

In summary, the chemistry of 4-Bromophenyl Isothiocyanate is characterized by its dual reactivity, making it a powerful tool for synthetic chemists. Its applications span from fundamental organic synthesis to the cutting-edge development of pharmaceuticals. Understanding its synthetic routes and reactivity profiles is key to unlocking its full potential in your research and production endeavors. We are here to support your chemical needs with our expert manufacturing capabilities.