Understanding the fundamental chemistry of key building blocks is essential for any successful synthetic endeavor. 4-Chloro-8-fluoroquinoline (CAS: 63010-72-0) is a fascinating molecule whose chemical properties and reactivity make it a valuable asset in organic synthesis. This article delves into the physical characteristics and the inherent reactivity of this important chemical intermediate, providing insights for chemists working with this compound.

Physically, 4-Chloro-8-fluoroquinoline is typically described as a white to light yellow powder. Its melting point range, often cited between 97-101 °C, indicates it is a solid under standard laboratory conditions. The molecular formula, C9H5ClFN, reveals a relatively small organic molecule with a molecular weight of 181.59 g/mol. These basic properties are crucial for handling, storage, and reaction planning. The compound's CAS number, 63010-72-0, serves as a unique identifier in databases and literature.

The reactivity of 4-Chloro-8-fluoroquinoline is largely dictated by its structural features. The quinoline ring system itself offers sites for electrophilic aromatic substitution, although these are less common due to the electron-withdrawing nature of the nitrogen atom and halogens. More significantly, the chlorine atom at the 4-position is susceptible to nucleophilic aromatic substitution (SNAr) reactions. This is a highly utilized pathway where the chlorine can be replaced by various nucleophiles, such as amines, alcohols, or thiols, allowing for the introduction of diverse functional groups. The fluorine atom at the 8-position, while generally less reactive than chlorine in SNAr, influences the electronic distribution within the ring and can affect the regioselectivity and rate of reactions at other positions.

Furthermore, the aromatic nature of the quinoline system allows for participation in metal-catalyzed cross-coupling reactions. For example, palladium-catalyzed reactions like Suzuki, Sonogashira, or Heck couplings can be performed at the chloro-substituted position, enabling the formation of carbon-carbon bonds and the construction of more elaborate molecular structures. The presence of the fluorine atom can sometimes modify the catalyst's efficiency or the reaction's outcome. These versatile reaction pathways underscore why 4-Chloro-8-fluoroquinoline is a prized chemical intermediate.

For researchers and manufacturers seeking this compound, sourcing from reliable suppliers like NINGBO INNO PHARMCHEM CO.,LTD. ensures access to material with consistent chemical properties and high purity (often ≥97%). This reliability is critical for achieving reproducible synthetic results. By understanding the chemistry of 4-Chloro-8-fluoroquinoline, chemists can better design synthetic routes and unlock its full potential.