Bioconjugation, the process of covalently linking two molecules, one of which is typically a biomolecule, has revolutionized fields ranging from diagnostics to targeted therapeutics. Central to many bioconjugation strategies is the maleimide functional group, and compounds like 4-Maleimidobenzoic Acid (CAS: 17057-04-4) are indispensable tools in this domain. As a leading manufacturer and supplier in China, we provide this essential chemical intermediate to empower groundbreaking research.

The primary utility of 4-Maleimidobenzoic Acid in bioconjugation stems from the inherent reactivity of its maleimide ring. This cyclic imide readily undergoes a highly selective Michael addition with free sulfhydryl (thiol) groups, typically found in cysteine residues of proteins. This reaction is efficient under mild physiological conditions, forming a stable thioether bond. This chemoselectivity is crucial for precisely attaching molecules to specific sites on biomolecules without disrupting their structure or function.

For pharmaceutical companies developing next-generation treatments, such as antibody-drug conjugates (ADCs), 4-Maleimidobenzoic Acid serves as a key linker component. It bridges the antibody (targeting moiety) to the cytotoxic payload, enabling targeted delivery to cancer cells. The benzoic acid portion of the molecule offers a convenient handle for further chemical modifications, such as coupling to other linker systems or drug molecules, thereby enhancing the versatility of the conjugation strategy. When you buy this intermediate, you are investing in a component that facilitates precise molecular assembly.

Procuring high-quality intermediates is essential for the success of such sophisticated applications. Our commitment as a manufacturer means we deliver 4-Maleimidobenzoic Acid with a guaranteed purity of 98% HPLC. This ensures the integrity of your conjugation reactions and the reliability of your final products. For procurement managers and researchers, sourcing directly from a reputable manufacturer like us in China offers not only quality assurance but also competitive pricing and dependable supply, critical for R&D continuity and commercial production.

Beyond ADCs, 4-Maleimidobenzoic Acid is utilized in creating fluorescently labeled proteins for imaging, developing diagnostic assays, and functionalizing surfaces with biomolecules for biosensors and medical devices. Its bifunctional nature allows for diverse applications, making it a staple in many biochemical and materials science laboratories. If your work involves precise molecular assembly and you are looking to buy a reliable source of this chemical, we are your trusted partner.

We encourage anyone involved in bioconjugation, drug discovery, or advanced materials to consider the benefits of using 4-Maleimidobenzoic Acid. As a dedicated manufacturer, we are here to support your endeavors by providing high-purity chemicals and expert service. Contact us today to request a quote and sample, and experience the reliability of sourcing from a leading supplier.