In the intricate world of pharmaceutical development, the precise synthesis of active pharmaceutical ingredients (APIs) often hinges on the availability of versatile and reliable chemical intermediates. Among these crucial building blocks, 2-Bromoacetophenone (CAS 70-11-1), also known by its common name Phenacyl bromide, has emerged as a compound of significant importance. Its distinct chemical structure and reactivity make it an indispensable tool for chemists engaged in the synthesis of complex molecules, particularly those destined for therapeutic applications.

2-Bromoacetophenone is characterized by its brominated ketone structure, a feature that endows it with unique reactivity, making it highly valuable in various organic synthesis pathways. The presence of the bromine atom, acting as a good leaving group, facilitates nucleophilic substitution reactions. This property allows for the controlled introduction of acetyl groups and other functional moieties onto organic molecules. This capability is not merely academic; it forms the bedrock of many critical synthetic routes in the pharmaceutical industry.

One of the most prominent applications of 2-Bromoacetophenone is its role as a key intermediate in the production of Ubenimex (CAS: 58970-76-6). Ubenimex is a compound recognized for its immunomodulatory and anticancer properties, making the synthesis of its precursors a critical step in pharmaceutical manufacturing. The reliable supply of high-purity 2-Bromoacetophenone is therefore essential to ensure the consistent production of such life-saving medications. Manufacturers who prioritize quality control measures, such as those adhering to stringent purity standards of ≥99%, ensure that the resulting pharmaceutical products meet rigorous regulatory requirements.

Beyond its direct role in Ubenimex synthesis, 2-Bromoacetophenone serves as a fundamental building block in broader fine chemical synthesis. Its ability to participate in reactions that yield diverse derivatives expands its utility, allowing researchers and manufacturers to explore new chemical entities. The consistent demand for this compound underscores its importance in the global chemical supply chain, with China emerging as a significant hub for its production. When sourcing this chemical, prospective buyers often look for manufacturers who can guarantee consistent quality and adherence to environmental regulations, ensuring a stable and reliable supply.

Understanding the physical and chemical properties of 2-Bromoacetophenone is also paramount for its effective use. With a melting point typically between 48-51°C and a density of around 1.476 g/cm³, it is generally handled as a crystalline solid. Proper storage, typically in a cool, dry, and well-closed container, away from moisture and strong light or heat, is crucial to maintain its integrity and efficacy. These careful handling practices ensure that the compound retains its specified properties, making it a dependable component in complex synthetic processes. The continued exploration of 2-Bromoacetophenone's applications promises further advancements in pharmaceutical synthesis and the development of novel therapeutic agents.