In the intricate world of organic synthesis, specialized building blocks are essential for creating complex molecules. N-Boc-2-pyrrolidinone, identified by its CAS number 85909-08-6, stands out as a particularly versatile and valuable intermediate. Its unique structure and reactivity profile make it indispensable for a wide array of chemical transformations, bridging the gap between basic starting materials and sophisticated end products. As a leading manufacturer and supplier, we understand the critical importance of high-quality intermediates like N-Boc-2-pyrrolidinone for the success of your research and production endeavors.

The chemical structure of N-Boc-2-pyrrolidinone features a pyrrolidinone ring protected with a tert-butoxycarbonyl (Boc) group. This protection strategy is widely employed in organic chemistry to temporarily block the reactivity of the nitrogen atom, allowing for selective modifications elsewhere in the molecule. The Boc group is readily introduced and, crucially, can be removed under mild acidic conditions, making N-Boc-2-pyrrolidinone an ideal precursor for a multitude of synthetic pathways.

One of the most significant applications of N-Boc-2-pyrrolidinone lies in its use within the Ugi reaction, a powerful multicomponent reaction capable of assembling complex molecular scaffolds in a single step. Specifically, it is employed to prepare highly functionalized N-acyl-2-vinylpyrrolidines. This capability is highly sought after in pharmaceutical research for the rapid generation of diverse compound libraries, accelerating the drug discovery process. By incorporating N-Boc-2-pyrrolidinone into your Ugi reaction protocols, you can efficiently synthesize novel compounds with potential therapeutic applications.

Beyond pharmaceutical applications, N-Boc-2-pyrrolidinone also finds utility in the synthesis of flavor compounds. Its conversion via catalytic SeO2 oxidation can lead to the formation of naturally occurring Maillard flavors, which are crucial for the food and beverage industry. This demonstrates the broad applicability of this intermediate across different sectors.

For procurement managers and research scientists looking to buy N-Boc-2-pyrrolidinone, understanding its properties is key. Typically appearing as a clear, colorless to brown oil, it exhibits properties such as a boiling point of 100-105 °C at 0.5 mmHg and a density of 1.086 g/mL at 25 °C. Its solubility in common organic solvents like chloroform and methanol further enhances its ease of use in various reaction conditions. When sourcing this critical intermediate, looking for a reliable manufacturer in China ensures competitive pricing and consistent quality.

The synthesis of N-Boc-2-pyrrolidinone itself often involves the reaction of 2-pyrrolidone with di-tert-butyl dicarbonate in the presence of a base. The detailed synthetic procedures are well-documented, ensuring reproducibility and scalability for industrial production. As a leading supplier, we are committed to providing N-Boc-2-pyrrolidinone that meets stringent purity requirements, typically exceeding 97%. This commitment ensures that our clients receive a product that will perform optimally in their demanding applications.

In conclusion, N-Boc-2-pyrrolidinone (CAS 85909-08-6) is a cornerstone intermediate for modern organic chemists. Its role in Ugi reactions for pharmaceutical synthesis and its utility in flavor development highlight its versatility. For businesses seeking to procure this essential chemical, partnering with a reputable manufacturer and supplier is paramount. We offer competitive pricing and exceptional product quality, making us your ideal partner for all your N-Boc-2-pyrrolidinone needs. Contact us today to inquire about bulk purchases or custom synthesis requirements.