Triisopropylsilane: A Deeper Dive into its Chemical Properties and Applications
Triisopropylsilane (TIPS), a key organosilicon compound with the CAS number 6485-79-6, possesses a unique set of chemical and physical properties that make it invaluable across several scientific disciplines, most notably in peptide synthesis and organic chemistry. As a prominent fine chemical supplier in China, we aim to provide comprehensive insights into the materials we offer.
Physically, Triisopropylsilane is a colorless liquid. Its molecular formula, C9H22Si, indicates a structure comprising a silicon atom bonded to three isopropyl groups and one hydrogen atom. This structure imparts specific characteristics, including its role as a tertiary silane. The Si-H bond is polar, with the silicon atom bearing a partial positive charge and the hydrogen atom a partial negative (hydridic) character. This polarity underpins its reactivity as both a reducing agent and a hydride donor.
In the context of peptide synthesis, TIPS is primarily utilized as a scavenger. During the critical deprotection stages of solid-phase peptide synthesis (SPPS), various reactive intermediates, particularly carbocations, can form. Triisopropylsilane efficiently intercepts these carbocations, preventing them from reacting with the growing peptide chain and causing unwanted modifications or chain termination. This protective action is crucial for obtaining high-purity peptides, making TIPS an essential component in the repertoire of peptide synthesis reagents.
Beyond its role in peptide synthesis, Triisopropylsilane serves as a versatile protecting group in organic chemistry. It can be employed to temporarily mask reactive functional groups, such as alcohols and amines, in complex synthetic sequences. The steric bulk of the isopropyl groups contributes to the selectivity of its reactions, and the silyl ether or silyl amine linkage can be cleaved under specific, often mild, conditions. This ability to selectively protect and deprotect is a hallmark of effective organic synthesis strategies.
For researchers and manufacturers relying on precise chemical intermediates, procuring high-quality Triisopropylsilane from a trusted manufacturer in China is essential. Our commitment to purity and consistency ensures that our Triisopropylsilane meets the demanding requirements for sensitive chemical reactions, supporting advancements in pharmaceuticals, materials science, and beyond.
Physically, Triisopropylsilane is a colorless liquid. Its molecular formula, C9H22Si, indicates a structure comprising a silicon atom bonded to three isopropyl groups and one hydrogen atom. This structure imparts specific characteristics, including its role as a tertiary silane. The Si-H bond is polar, with the silicon atom bearing a partial positive charge and the hydrogen atom a partial negative (hydridic) character. This polarity underpins its reactivity as both a reducing agent and a hydride donor.
In the context of peptide synthesis, TIPS is primarily utilized as a scavenger. During the critical deprotection stages of solid-phase peptide synthesis (SPPS), various reactive intermediates, particularly carbocations, can form. Triisopropylsilane efficiently intercepts these carbocations, preventing them from reacting with the growing peptide chain and causing unwanted modifications or chain termination. This protective action is crucial for obtaining high-purity peptides, making TIPS an essential component in the repertoire of peptide synthesis reagents.
Beyond its role in peptide synthesis, Triisopropylsilane serves as a versatile protecting group in organic chemistry. It can be employed to temporarily mask reactive functional groups, such as alcohols and amines, in complex synthetic sequences. The steric bulk of the isopropyl groups contributes to the selectivity of its reactions, and the silyl ether or silyl amine linkage can be cleaved under specific, often mild, conditions. This ability to selectively protect and deprotect is a hallmark of effective organic synthesis strategies.
For researchers and manufacturers relying on precise chemical intermediates, procuring high-quality Triisopropylsilane from a trusted manufacturer in China is essential. Our commitment to purity and consistency ensures that our Triisopropylsilane meets the demanding requirements for sensitive chemical reactions, supporting advancements in pharmaceuticals, materials science, and beyond.
Perspectives & Insights
Bio Analyst 88
“The Si-H bond is polar, with the silicon atom bearing a partial positive charge and the hydrogen atom a partial negative (hydridic) character.”
Nano Seeker Pro
“This polarity underpins its reactivity as both a reducing agent and a hydride donor.”
Data Reader 7
“During the critical deprotection stages of solid-phase peptide synthesis (SPPS), various reactive intermediates, particularly carbocations, can form.”