Triisopropylsilyl Chloride (TIPSCl): Handling, Properties, and Synthesis Essentials
Triisopropylsilyl Chloride (TIPSCl), a widely used organosilicon compound with CAS number 13154-24-0, is a critical reagent in various chemical applications, particularly in organic synthesis and as a pharmaceutical intermediate. Understanding its fundamental properties, safe handling procedures, and synthesis methods is crucial for effective utilization by researchers and chemical professionals.
Physically, Triisopropylsilyl Chloride is a colorless, clear liquid with a distinctive acrid odor. It possesses a molecular weight of approximately 192.8 g/mol. Key physical properties include a boiling point of around 198°C at 739 mmHg, a flash point of approximately 62°C, and a density of 0.901 g/mL at 25°C. Its refractive index is recorded at n20/D 1.452. These characteristics highlight its stability under normal laboratory conditions, but also indicate the need for careful handling, especially concerning its moderate flammability.
A significant property of TIPSCl is its reactivity with moisture. It is sensitive to water and protic solvents, readily undergoing hydrolysis. Therefore, it must be stored in tightly sealed containers, preferably under an inert atmosphere, in a cool, dry, and well-ventilated area to prevent degradation and maintain its purity and reactivity. Standard laboratory safety precautions, such as wearing appropriate personal protective equipment (gloves, eye protection, lab coat) and working in a fume hood, are essential when handling this corrosive liquid.
The synthesis of Triisopropylsilyl Chloride can be achieved through several methods. One common route involves the chlorination of triisopropylsilane using hydrochloric acid. Another approach utilizes silicon tetrachloride reacted with isopropyl lithium. More specific methods might involve the reaction of triisopropylmethoxysilane or triisopropyl n-butoxysilane with concentrated hydrochloric acid. These synthesis pathways are optimized to yield the product with high purity, typically exceeding 97% or 99% as determined by gas chromatography.
NINGBO INNO PHARMCHEM CO.,LTD. specializes in providing high-quality Triisopropylsilyl Chloride, ensuring that our customers receive a product that meets rigorous specifications for their demanding applications. Whether you are involved in complex organic synthesis, developing novel materials, or manufacturing pharmaceutical intermediates, our reliable supply of TIPSCl can support your endeavors.
In summary, Triisopropylsilyl Chloride is a vital chemical reagent characterized by its utility as a silylating agent and protecting group. Its specific physical and chemical properties necessitate careful handling and storage, while its synthesis involves established organosilicon chemistry techniques. By understanding these essentials, professionals can confidently and effectively leverage Triisopropylsilyl Chloride in their research and industrial processes.
Physically, Triisopropylsilyl Chloride is a colorless, clear liquid with a distinctive acrid odor. It possesses a molecular weight of approximately 192.8 g/mol. Key physical properties include a boiling point of around 198°C at 739 mmHg, a flash point of approximately 62°C, and a density of 0.901 g/mL at 25°C. Its refractive index is recorded at n20/D 1.452. These characteristics highlight its stability under normal laboratory conditions, but also indicate the need for careful handling, especially concerning its moderate flammability.
A significant property of TIPSCl is its reactivity with moisture. It is sensitive to water and protic solvents, readily undergoing hydrolysis. Therefore, it must be stored in tightly sealed containers, preferably under an inert atmosphere, in a cool, dry, and well-ventilated area to prevent degradation and maintain its purity and reactivity. Standard laboratory safety precautions, such as wearing appropriate personal protective equipment (gloves, eye protection, lab coat) and working in a fume hood, are essential when handling this corrosive liquid.
The synthesis of Triisopropylsilyl Chloride can be achieved through several methods. One common route involves the chlorination of triisopropylsilane using hydrochloric acid. Another approach utilizes silicon tetrachloride reacted with isopropyl lithium. More specific methods might involve the reaction of triisopropylmethoxysilane or triisopropyl n-butoxysilane with concentrated hydrochloric acid. These synthesis pathways are optimized to yield the product with high purity, typically exceeding 97% or 99% as determined by gas chromatography.
NINGBO INNO PHARMCHEM CO.,LTD. specializes in providing high-quality Triisopropylsilyl Chloride, ensuring that our customers receive a product that meets rigorous specifications for their demanding applications. Whether you are involved in complex organic synthesis, developing novel materials, or manufacturing pharmaceutical intermediates, our reliable supply of TIPSCl can support your endeavors.
In summary, Triisopropylsilyl Chloride is a vital chemical reagent characterized by its utility as a silylating agent and protecting group. Its specific physical and chemical properties necessitate careful handling and storage, while its synthesis involves established organosilicon chemistry techniques. By understanding these essentials, professionals can confidently and effectively leverage Triisopropylsilyl Chloride in their research and industrial processes.
Perspectives & Insights
Future Origin 2025
“Understanding its fundamental properties, safe handling procedures, and synthesis methods is crucial for effective utilization by researchers and chemical professionals.”
Core Analyst 01
“Physically, Triisopropylsilyl Chloride is a colorless, clear liquid with a distinctive acrid odor.”
Silicon Seeker One
“Key physical properties include a boiling point of around 198°C at 739 mmHg, a flash point of approximately 62°C, and a density of 0.”