Understanding 1,4-Dibromobenzene: Properties, Synthesis, and Industrial Use
1,4-Dibromobenzene, identified by its CAS number 106-37-6, is an organic compound characterized by a benzene ring with two bromine atoms situated at opposite (para) positions. This symmetrical structure imparts distinct physical and chemical properties that make it a valuable commodity in the chemical industry. Understanding these attributes is key to appreciating its diverse applications.
Physically, 1,4-Dibromobenzene typically presents as a white to off-white crystalline powder. It has a melting point in the range of 83-87°C and a boiling point of approximately 219°C. Its solubility profile indicates it is soluble in common organic solvents like alcohol, benzene, and chloroform, but insoluble in ether. These properties are crucial for its handling and use in various chemical processes, from synthesis to formulation.
While direct synthesis methods are often proprietary to manufacturers, 1,4-Dibromobenzene is generally produced through the bromination of benzene. This process involves reacting benzene with bromine in the presence of a Lewis acid catalyst, such as iron(III) bromide, which directs the substitution to the para position due to the existing bromine atom's ortho, para-directing nature. Achieving high selectivity for the para isomer is important for obtaining the desired purity of 1,4-Dibromobenzene.
The industrial utility of 1,4-Dibromobenzene spans several key sectors. As a crucial organic intermediate, it is widely employed in the synthesis of pharmaceuticals, agrochemicals, and dyes. Its reactive bromine atoms serve as excellent leaving groups or sites for further functionalization through reactions like Grignard or organolithium formations, as well as various cross-coupling reactions. This makes it an indispensable tool for constructing complex molecular structures required in these industries.
Furthermore, 1,4-Dibromobenzene finds applications as a heavy liquid solvent and has been noted for its use as a motor oil additive. Its role in producing flame retardants for polymeric materials also highlights its contribution to enhanced product safety. For those involved in chemical research and development, understanding the availability of high-purity 1,4-Dibromobenzene from reputable suppliers is vital for successful project outcomes. The emphasis on quality and purity from leading chemical manufacturers ensures its reliable performance in demanding applications.
Physically, 1,4-Dibromobenzene typically presents as a white to off-white crystalline powder. It has a melting point in the range of 83-87°C and a boiling point of approximately 219°C. Its solubility profile indicates it is soluble in common organic solvents like alcohol, benzene, and chloroform, but insoluble in ether. These properties are crucial for its handling and use in various chemical processes, from synthesis to formulation.
While direct synthesis methods are often proprietary to manufacturers, 1,4-Dibromobenzene is generally produced through the bromination of benzene. This process involves reacting benzene with bromine in the presence of a Lewis acid catalyst, such as iron(III) bromide, which directs the substitution to the para position due to the existing bromine atom's ortho, para-directing nature. Achieving high selectivity for the para isomer is important for obtaining the desired purity of 1,4-Dibromobenzene.
The industrial utility of 1,4-Dibromobenzene spans several key sectors. As a crucial organic intermediate, it is widely employed in the synthesis of pharmaceuticals, agrochemicals, and dyes. Its reactive bromine atoms serve as excellent leaving groups or sites for further functionalization through reactions like Grignard or organolithium formations, as well as various cross-coupling reactions. This makes it an indispensable tool for constructing complex molecular structures required in these industries.
Furthermore, 1,4-Dibromobenzene finds applications as a heavy liquid solvent and has been noted for its use as a motor oil additive. Its role in producing flame retardants for polymeric materials also highlights its contribution to enhanced product safety. For those involved in chemical research and development, understanding the availability of high-purity 1,4-Dibromobenzene from reputable suppliers is vital for successful project outcomes. The emphasis on quality and purity from leading chemical manufacturers ensures its reliable performance in demanding applications.
Perspectives & Insights
Nano Explorer 01
“For those involved in chemical research and development, understanding the availability of high-purity 1,4-Dibromobenzene from reputable suppliers is vital for successful project outcomes.”
Data Catalyst One
“The emphasis on quality and purity from leading chemical manufacturers ensures its reliable performance in demanding applications.”
Chem Thinker Labs
“1,4-Dibromobenzene, identified by its CAS number 106-37-6, is an organic compound characterized by a benzene ring with two bromine atoms situated at opposite (para) positions.”