For chemists and product formulators, a deep understanding of chemical intermediates is vital for successful product development. 1-Bromo-4-nitrobenzene (CAS 586-78-7) is a compound that warrants detailed attention due to its diverse reactivity and utility in various synthetic processes. As a leading chemical supplier, we aim to provide clarity on this essential intermediate, guiding professionals on its properties and how to effectively utilize it in their work.

1-Bromo-4-nitrobenzene is a pale yellow to cream-colored crystalline solid. Its molecular structure, featuring a bromine atom and a nitro group attached to a benzene ring in a para-arrangement, dictates its chemical behavior. The electron-withdrawing nature of the nitro group activates the benzene ring towards certain reactions while also influencing the reactivity of the bromine atom. This dual functionality makes it a valuable component in organic synthesis.

The key applications of 1-Bromo-4-nitrobenzene are primarily rooted in its role as a synthetic intermediate. Chemists often use it in electrophilic aromatic substitution reactions to introduce nitro groups, a common step in creating more complex organic molecules. The bromine substituent can also be a leaving group in nucleophilic substitution reactions or can participate in various metal-catalyzed cross-coupling reactions, such as Suzuki-Miyaura coupling, Stille coupling, or Heck reactions. These processes are fundamental in building carbon-carbon bonds, which is essential for constructing pharmaceuticals, agrochemicals, and advanced materials.

Specifically, 1-Bromo-4-nitrobenzene serves as a precursor for:

  • Amines: Reduction of the nitro group yields 4-bromoaniline, a critical intermediate for dyes, pharmaceuticals, and polymers.
  • Aryl Derivatives: Through various coupling reactions, the bromine can be replaced with different functional groups, allowing for the synthesis of highly functionalized aromatic compounds.
  • Heterocyclic Compounds: It can be a starting material for constructing various heterocyclic ring systems, which are prevalent in many biologically active molecules.

For businesses looking to buy 1-Bromo-4-nitrobenzene, understanding its specifications is crucial. Typical product specifications include a purity of 98% or higher, a melting point in the range of 124-127°C, and a boiling point around 255-256°C. Availability of comprehensive technical documentation, such as TDS and SDS, from the manufacturer is also a key factor. When seeking a reliable supplier, focusing on those with robust quality control and efficient logistics, particularly those operating from regions like China, can ensure a stable and cost-effective supply chain.

In conclusion, 1-Bromo-4-nitrobenzene is a cornerstone intermediate for many synthetic chemists. Its unique reactivity profile enables a wide range of transformations essential for creating valuable end products. We encourage researchers and production managers to consider us as your preferred supplier of 1-Bromo-4-nitrobenzene, offering high-quality material at competitive prices to support your chemical synthesis needs.