The intricate tapestry of modern organic chemistry is woven with versatile building blocks that enable the construction of complex molecules. Among these essential components, 1-Fluoro-4-iodobenzene (CAS 352-34-1) stands out due to its dual functionality and broad applicability. This aryl halide is instrumental in areas ranging from pharmaceutical synthesis to advanced materials development. For researchers and industrial chemists, understanding its properties and applications, and knowing how to effectively buy this compound, is key to unlocking scientific and commercial potential.

1-Fluoro-4-iodobenzene, also known as p-fluoroiodobenzene, is a substituted benzene ring containing a fluorine atom and an iodine atom in a para configuration. This specific arrangement imparts unique reactivity. The electron-withdrawing nature of the fluorine atom activates the aromatic ring and influences the reactivity of the carbon-iodine bond, making it an excellent substrate for a variety of metal-catalyzed cross-coupling reactions. These include the widely used Suzuki-Miyaura coupling (for C-C bond formation), Sonogashira coupling (for C-C alkyne bond formation), and Buchwald-Hartwig amination (for C-N bond formation). These reactions are indispensable tools for chemists aiming to construct complex molecular architectures.

The utility of 1-Fluoro-4-iodobenzene is particularly evident in the pharmaceutical industry. It serves as a critical intermediate in the synthesis of numerous Active Pharmaceutical Ingredients (APIs). Its fluorinated aromatic ring can be incorporated into drug candidates to improve properties such as metabolic stability, lipophilicity, and target binding affinity. For instance, it is a key component in the synthesis of certain kinase inhibitors, which are vital in cancer therapy. Companies engaged in drug development often seek to purchase this intermediate from reliable manufacturers to ensure the purity and consistency required for pharmaceutical-grade materials.

Beyond pharmaceuticals, 1-Fluoro-4-iodobenzene finds applications in materials science, notably in the synthesis of liquid crystals and organic electronic materials. The inclusion of fluorine atoms can significantly influence the electronic and optical properties of these materials, leading to improved performance in displays, sensors, and other advanced technological devices. When developing new materials, accessing high-purity building blocks like this is essential for achieving desired performance characteristics. It is therefore important to understand the price and availability from established chemical suppliers.

For procurement specialists and R&D teams, sourcing 1-Fluoro-4-iodobenzene (CAS 352-34-1) requires diligence. It is advisable to work with manufacturers who can provide comprehensive technical data, including Certificates of Analysis (CoA), detailing purity (typically ≥99%), melting point, boiling point, and other critical parameters. Suppliers based in China often offer competitive pricing and substantial production capacities, making them attractive partners for global businesses. Investigating their export experience and commitment to quality control is crucial before placing an order.

In conclusion, 1-Fluoro-4-iodobenzene is a highly versatile and important chemical building block. Its role in pharmaceutical synthesis, materials science, and other advanced chemical applications underscores its value. When the need arises to buy this compound, focusing on purity, reliability of supply, and competitive pricing from reputable manufacturers will ensure the success of your projects.