2'-Fluoropropiophenone, identified by its CAS number 446-22-0, is a significant chemical intermediate with a range of applications, particularly in organic synthesis. This article provides a detailed overview of its properties, common uses, and essential information for professionals looking to purchase and handle this compound.

Chemically, 2'-Fluoropropiophenone is a fluorinated propiophenone derivative. Its molecular formula is C9H9FO, and it has a molecular weight of approximately 152.17 g/mol. Physically, it typically appears as a pale yellow oil. Key properties reported include a boiling point of 95-99 °C at 19 mmHg and a density of 1.102 g/mL at 25 °C. Its refractive index is around 1.5043. For storage, it is recommended to keep it sealed in a dry environment, preferably between 2-8°C, to maintain its stability.

In terms of solubility, 2'-Fluoropropiophenone is soluble in common organic solvents such as chloroform and methanol, but it is not miscible with water. This characteristic is important for planning reaction conditions and purification processes. Safety information indicates it is a combustible liquid and can cause skin and serious eye irritation, necessitating appropriate personal protective equipment (PPE) when handling. Standard precautionary statements include keeping it away from heat and sparks, and wearing protective gloves and eye protection.

The primary utility of 2'-Fluoropropiophenone lies in its role as a versatile intermediate in organic synthesis. It serves as a valuable building block for creating more complex molecules, finding applications in the pharmaceutical industry for developing new APIs, and in the agrochemical sector for synthesizing advanced crop protection agents. Researchers and manufacturers often buy this compound for its reactivity and the specific properties it can impart to target molecules.

For those looking to procure 2'-Fluoropropiophenone, understanding its availability from reliable manufacturers and suppliers is key. Whether you are a research scientist or a procurement manager, searching for terms like 'buy 2'-fluoropropiophenone' or 'CAS 446-22-0 supplier' will connect you with providers. It's advisable to compare purity levels, pricing, and packaging options to meet your specific project needs. By understanding its properties and applications, professionals can effectively integrate 2'-Fluoropropiophenone into their chemical processes.