In the realm of chemical manufacturing, understanding the properties, synthesis, and sourcing of key intermediates is fundamental to success. 4-Bromoveratrole (CAS: 2859-78-1) is one such vital compound, a colorless transparent liquid widely employed as a building block in various industries. This article aims to provide a comprehensive overview for chemical professionals looking to source and utilize this important intermediate.

Key Properties of 4-Bromoveratrole:

4-Bromoveratrole, with the molecular formula C8H9BrO2 and a molecular weight of 217.06, exhibits several important physical and chemical characteristics:

  • Appearance: Colorless transparent liquid.
  • Purity: Typically available at a purity of ≥98.0%.
  • CAS Number: 2859-78-1
  • Chemical Name: 4-Bromo-1,2-dimethoxybenzene; commonly known as 4-Bromoveratrole.
  • Synonyms: 3,4-Dimethoxybromobenzene, p-Bromoveratrole, 4-Bromoveratrol, 4-Bromocatechol dimethyl ether.
  • Boiling Point: Approximately 255-256 °C at atmospheric pressure.
  • Density: Around 1.509 g/mL at 25 °C.

These properties make it suitable for reactions requiring specific physical states and purity levels, such as in pharmaceutical and agrochemical synthesis.

Common Synthesis Routes

The synthesis of 4-Bromoveratrole typically involves the bromination of veratrole (1,2-dimethoxybenzene). Common methods include:

  • Electrophilic Aromatic Substitution: Reacting veratrole with a brominating agent, such as bromine in acetic acid or N-bromosuccinimide (NBS), under controlled conditions to achieve regioselective bromination at the para position to one of the methoxy groups.
  • Oxidative Coupling: Some advanced methods might involve oxidative coupling strategies, though direct bromination is generally more common for industrial scale.

Ensuring high purity often requires post-synthesis purification steps, such as distillation or recrystallization, depending on the specific process and required end-product quality.

Sourcing Strategies for Manufacturers

For companies looking to buy 4-Bromoveratrole, especially in bulk for industrial applications, several factors are crucial when selecting a supplier:

  1. Manufacturer vs. Distributor: Sourcing directly from a manufacturer can often lead to better pricing and more direct quality control.
  2. Purity Assurance: Always request a Certificate of Analysis (COA) that details the purity and any significant impurities. For demanding applications, verification of analytical methods (e.g., GC-MS, NMR) is important.
  3. Production Capacity and Reliability: Ensure the supplier can meet your volume requirements consistently. A stable supply chain is vital for uninterrupted production schedules.
  4. Regulatory Compliance: For pharmaceutical and agrochemical applications, understanding the supplier's quality management systems (e.g., ISO certification) is beneficial.
  5. Competitive Pricing: Obtain quotes from multiple reputable suppliers to ensure you are getting a fair market price for high-quality material.

Partnering with a Trusted Supplier

As a dedicated manufacturer and supplier of high-purity chemical intermediates, we offer 4-Bromoveratrole (CAS 2859-78-1) that meets stringent quality standards. Our commitment to consistent production and reliable supply makes us an ideal partner for your synthesis needs. We understand the importance of quality in your end products and are dedicated to providing the necessary support, from product specifications to timely delivery. If you are looking to purchase 4-Bromoveratrole, we encourage you to contact us for detailed information, pricing, and a sample to evaluate.