In the intricate world of chemical synthesis, certain compounds stand out due to their versatility and critical role in developing new materials and therapeutics. 4-Nitrophenyl Isothiocyanate (often abbreviated as 4-NPIC) is one such compound, recognized for its reactivity and broad applicability. This article delves into what 4-NPIC is, how it's produced, its primary uses, and how procurement professionals and researchers can ensure a stable supply from reputable manufacturers.

What is 4-Nitrophenyl Isothiocyanate?

4-Nitrophenyl Isothiocyanate, identified by CAS number 2131-61-5, is an organic compound characterized by its yellow crystalline solid appearance. Its molecular formula is C₇H₄N₂O₂S. The molecule features an isothiocyanate functional group (-N=C=S) attached to a nitrophenyl ring. This specific structure imbues it with significant electrophilicity, making it a highly reactive intermediate in various chemical reactions, particularly with nucleophiles.

Synthesis and Production Methods

The synthesis of 4-Nitrophenyl Isothiocyanate typically involves the reaction of 4-nitroaniline with thiophosgene. This chemical transformation requires careful handling due to the nature of thiophosgene. Industrial production methods focus on optimizing yield and purity, often employing controlled conditions and advanced manufacturing techniques. For those looking to buy this compound, understanding the production process highlights the importance of sourcing from experienced manufacturers who prioritize safety and quality control.

Key Applications in Research and Industry

The utility of 4-NPIC spans several critical domains:

1. Organic Synthesis: It serves as a fundamental building block for synthesizing a wide array of organic compounds. Its reaction with amines yields thiourea derivatives, which are precursors for many biologically active molecules and advanced materials. Researchers often seek this compound for its ability to facilitate complex molecular constructions.

2. Pharmaceutical Intermediates: The ability to form thiourea and other nitrogen-sulfur containing structures makes 4-NPIC invaluable in the development of pharmaceutical intermediates. Its incorporation into drug candidates can lead to novel therapeutic agents. When searching for chemical intermediates, 4-NPIC is a key term for those in pharmaceutical R&D.

3. Biochemical Studies: 4-NPIC can be used for labeling proteins and peptides. By reacting with amino groups, it allows scientists to study protein-protein interactions, track protein localization, and analyze protein function. This application underscores its importance for researchers in biochemistry and molecular biology.

4. Material Science: Derivatives of 4-NPIC, such as polythioureas, are being explored for their self-healing properties in materials science, pointing towards future applications in advanced materials.

Sourcing 4-Nitrophenyl Isothiocyanate: Price and Suppliers

For procurement managers and R&D scientists, identifying a reliable supplier for 4-Nitrophenyl Isothiocyanate is crucial. When considering a purchase, factors like purity, batch consistency, lead times, and price are paramount. China has emerged as a significant global hub for fine chemical manufacturing, offering competitive pricing and a wide range of suppliers for compounds like 4-NPIC. Engaging with established manufacturers or their authorized distributors ensures quality and adherence to industry standards. Exploring options to obtain a quote from multiple vendors can help secure the best terms and ensure a stable supply chain for your ongoing projects.

In conclusion, 4-Nitrophenyl Isothiocyanate is a vital chemical intermediate with diverse applications. Understanding its properties and sourcing effectively from reputable manufacturers and suppliers is key to advancing research and product development in chemistry, pharmaceuticals, and beyond.