Understanding 5-Chlorovaleryl Chloride: Properties, Synthesis, and Market Significance
5-Chlorovaleryl Chloride, identified by the CAS number 1575-61-7, is a chemical compound that holds significant market importance primarily due to its versatile applications as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This article provides a detailed look into its key properties, common synthesis routes, and its overall significance in the global chemical market.
The chemical profile of 5-Chlorovaleryl Chloride is characterized by its physical state: a clear, colorless to slightly yellow liquid. It exhibits a boiling point of approximately 38-39 °C at low pressure (0.15 mm Hg) and a density of around 1.206 g/mL at 20 °C. These physical parameters are crucial for chemical engineers and manufacturers when designing processing and handling protocols. Its molecular formula, C5H8Cl2O, and molecular weight of 155.02 g/mol further define its chemical identity.
The synthesis of 5-Chlorovaleryl Chloride is a multi-step process that showcases the expertise required in fine chemical manufacturing. A standard industrial method often begins with 1,4-dichlorobutane. This raw material is converted into 5-chlorovaleronitrile, then hydrolyzed to form 5-chlorovaleric acid, and finally reacted with thionyl chloride to produce the desired 5-Chlorovaleryl Chloride. The optimization of these stages is critical to achieving high yields and purity levels, often exceeding 99%, which is essential for its downstream applications in high-stakes industries like pharmaceuticals.
The primary function of 5-Chlorovaleryl Chloride is as an alkylating agent. This chemical reactivity is instrumental in the synthesis of valuable end-products. In the pharmaceutical industry, it is a key raw material for manufacturing drugs such as Cilostazol, which is used to improve blood flow and alleviate symptoms of intermittent claudication. Its role in the agrochemical sector is equally vital, serving as an intermediate for herbicides like Pyraclonil, known for its potent weed-control properties and environmental compatibility. These applications underscore the compound's economic and practical significance.
Companies like NINGBO INNO PHARMCHEM CO.,LTD. are key players in the supply chain, providing high-quality 5-Chlorovaleryl Chloride to meet global demand. Their commitment to rigorous quality control and efficient production processes ensures that manufacturers receive a reliable supply of this essential intermediate. The market for such chemical building blocks is driven by the continuous innovation in drug development and the need for advanced crop protection solutions.
In addition to its major roles, 5-Chlorovaleryl Chloride also finds niche applications in areas like materials science, for example, in the synthesis of anion-exchange resins. This versatility further enhances its market value and ensures its continued relevance in various industrial processes. As the demand for specialized chemicals grows, intermediates like 5-Chlorovaleryl Chloride will continue to be foundational elements of innovation.
In summary, 5-Chlorovaleryl Chloride is a cornerstone chemical intermediate whose well-defined properties, efficient synthesis, and critical applications in the pharmaceutical and agrochemical industries make it a compound of significant market importance. Its role as an alkylating agent facilitates the creation of products vital to human health and agricultural productivity.
The chemical profile of 5-Chlorovaleryl Chloride is characterized by its physical state: a clear, colorless to slightly yellow liquid. It exhibits a boiling point of approximately 38-39 °C at low pressure (0.15 mm Hg) and a density of around 1.206 g/mL at 20 °C. These physical parameters are crucial for chemical engineers and manufacturers when designing processing and handling protocols. Its molecular formula, C5H8Cl2O, and molecular weight of 155.02 g/mol further define its chemical identity.
The synthesis of 5-Chlorovaleryl Chloride is a multi-step process that showcases the expertise required in fine chemical manufacturing. A standard industrial method often begins with 1,4-dichlorobutane. This raw material is converted into 5-chlorovaleronitrile, then hydrolyzed to form 5-chlorovaleric acid, and finally reacted with thionyl chloride to produce the desired 5-Chlorovaleryl Chloride. The optimization of these stages is critical to achieving high yields and purity levels, often exceeding 99%, which is essential for its downstream applications in high-stakes industries like pharmaceuticals.
The primary function of 5-Chlorovaleryl Chloride is as an alkylating agent. This chemical reactivity is instrumental in the synthesis of valuable end-products. In the pharmaceutical industry, it is a key raw material for manufacturing drugs such as Cilostazol, which is used to improve blood flow and alleviate symptoms of intermittent claudication. Its role in the agrochemical sector is equally vital, serving as an intermediate for herbicides like Pyraclonil, known for its potent weed-control properties and environmental compatibility. These applications underscore the compound's economic and practical significance.
Companies like NINGBO INNO PHARMCHEM CO.,LTD. are key players in the supply chain, providing high-quality 5-Chlorovaleryl Chloride to meet global demand. Their commitment to rigorous quality control and efficient production processes ensures that manufacturers receive a reliable supply of this essential intermediate. The market for such chemical building blocks is driven by the continuous innovation in drug development and the need for advanced crop protection solutions.
In addition to its major roles, 5-Chlorovaleryl Chloride also finds niche applications in areas like materials science, for example, in the synthesis of anion-exchange resins. This versatility further enhances its market value and ensures its continued relevance in various industrial processes. As the demand for specialized chemicals grows, intermediates like 5-Chlorovaleryl Chloride will continue to be foundational elements of innovation.
In summary, 5-Chlorovaleryl Chloride is a cornerstone chemical intermediate whose well-defined properties, efficient synthesis, and critical applications in the pharmaceutical and agrochemical industries make it a compound of significant market importance. Its role as an alkylating agent facilitates the creation of products vital to human health and agricultural productivity.
Perspectives & Insights
Molecule Vision 7
“This article provides a detailed look into its key properties, common synthesis routes, and its overall significance in the global chemical market.”
Alpha Origin 24
“The chemical profile of 5-Chlorovaleryl Chloride is characterized by its physical state: a clear, colorless to slightly yellow liquid.”
Future Analyst X
“These physical parameters are crucial for chemical engineers and manufacturers when designing processing and handling protocols.”