For chemists engaged in diverse synthetic pathways, understanding the properties and applications of key intermediates is fundamental. 8-Bromo-1-octene (CAS: 2695-48-9) is a valuable organobromine compound that offers significant utility in organic synthesis. This colorless transparent liquid, characterized by its terminal alkene and alkyl bromide functionalities, serves as a versatile building block for complex molecule construction. If you're looking to buy this compound, this guide provides essential information.

Chemical Identity and Properties:

8-Bromo-1-octene, with the molecular formula C8H15Br and a molecular weight of 191.11 g/mol, is identified by CAS number 2695-48-9. Its physical properties include a density of approximately 1.139 g/mL at 25 °C and a boiling point of around 198.7 °C at atmospheric pressure. Its refractive index is typically 1.467. The presence of the terminal double bond and the primary bromide makes it amenable to a wide array of chemical reactions, crucial for efficient synthesis.

Key Synthesis Applications:

The primary utility of 8-Bromo-1-octene lies in its role as a versatile intermediate. It is widely employed in:

  • Pharmaceutical Synthesis: As a building block for creating complex pharmaceutical compounds, such as derivatives of Dithienogermole (DTG), where precise control over alkyl chain length and pendant functionalities is required.
  • Grignard Reagent Formation: The alkyl bromide moiety readily converts into a Grignard reagent (C8H15MgBr), a powerful nucleophile used extensively for carbon-carbon bond formation in the synthesis of pharmaceuticals and natural products.
  • Material Science: It finds application in the synthesis of polymerizable ligands, which are then used to create functionalized polymer beads, for instance, quantum dot-labeled polymer beads.
  • Natural Product Synthesis: Its structure allows for its incorporation into the synthetic routes of various natural products, contributing to their complex architectures.

Sourcing and Quality Assurance:

When chemists decide to buy 8-Bromo-1-octene, ensuring high purity is paramount for successful reaction outcomes. Purity levels of 97.0% or higher are commonly sought. Sourcing from reputable manufacturers and suppliers, particularly those in China known for their expertise in fine chemical intermediates, is advisable. Look for suppliers who can provide comprehensive technical data, including CAS number, specifications, and safety information. Obtaining a quote from multiple suppliers can also help ensure competitive pricing.

Handling and Storage:

Proper handling and storage are essential for maintaining the quality of 8-Bromo-1-octene. It should be stored in a cool, dry, and well-ventilated area, preferably under an inert atmosphere, and kept away from incompatible materials like strong oxidizers. As a chemical intermediate, adherence to safety data sheets (SDS) for handling is crucial.

Conclusion:

8-Bromo-1-octene is a highly valuable intermediate for chemists involved in advanced organic synthesis, pharmaceutical development, and material science. Its dual functionality allows for diverse chemical transformations. By understanding its properties and ensuring procurement from reliable sources, chemists can effectively leverage this compound to achieve their synthetic goals. Contact a trusted manufacturer today to inquire about pricing and availability.