For professionals in the field of organic synthesis and peptide chemistry, understanding the specific properties of key reagents is fundamental to successful experimentation and production. CAS Number 136849-72-4 identifies TOTU, a critical coupling reagent that has gained significant traction for its efficacy in forming peptide bonds. This article aims to provide a comprehensive overview of TOTU, its chemical attributes, and its significance, guiding you on how to procure this essential compound. If you need to buy TOTU, knowing its CAS number is a starting point for quality assurance.

The Chemical Identity of TOTU (CAS 136849-72-4)

TOTU, formally known as O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate, is characterized by its unique uronium salt structure. This molecular architecture is key to its function as an efficient activating agent for carboxylic acids, facilitating the formation of amide bonds essential in peptide synthesis. The tetrafluoroborate counterion contributes to its stability and solubility in common organic solvents used in synthesis. Understanding these chemical properties helps in optimizing reaction conditions when you buy TOTU for your specific applications.

Key Properties and Benefits of TOTU

The primary advantage of using TOTU is its high efficiency in promoting peptide coupling reactions. It activates amino acids swiftly, leading to rapid bond formation and often higher yields compared to older coupling reagents. Moreover, TOTU is recognized for its low tendency to cause racemization of the activated amino acid, a critical factor in peptide synthesis where stereochemical purity is paramount. This makes it an ideal choice for synthesizing peptides with specific biological activities, particularly for pharmaceutical research and development. As a supplier, we ensure our TOTU meets the high standards required for these applications.

Applications and Sourcing Considerations

TOTU finds extensive application in both solid-phase and solution-phase peptide synthesis. It is particularly valued for its performance in demanding couplings, such as those involving sterically hindered amino acids or when synthesizing complex peptide sequences. For researchers and manufacturers seeking to buy TOTU, it is crucial to source from a reliable manufacturer that guarantees product purity and consistency. Our company is a trusted source for high-quality TOTU, offering competitive prices and dependable supply. We are happy to provide quotations for your specific needs, ensuring you receive the best value for this vital reagent.

Procuring High-Purity TOTU

When your synthesis requires the precision offered by TOTU, choosing the right supplier is critical. We pride ourselves on being a premier manufacturer and supplier of this essential peptide coupling reagent. Understanding the importance of CAS 136849-72-4 ensures you are purchasing the correct compound with the expected properties. Contact us today to learn more about our TOTU product, discuss your project requirements, and secure a reliable supply chain for your research and manufacturing endeavors.