Potassium Tert-Butoxide, identified by its CAS number 865-47-4, is a highly reactive chemical compound widely recognized for its utility in organic synthesis. Its physical form is typically a white powder, with a molecular formula of C4H9KO and a molecular weight of 112.21. While its primary function is that of a strong base, understanding its inherent properties and the necessary precautions for handling is critical for safe and effective use. For researchers and industrial chemists, sourcing this reagent from reputable suppliers, often found in China, is a common practice.

The strength of Potassium Tert-Butoxide as a base is one of its most defining characteristics. It possesses a high pKa, making it exceptionally effective at deprotonating weak acids, a fundamental step in many organic reactions. Importantly, its bulky tert-butyl group confers non-nucleophilic properties, preventing it from acting as a nucleophile and thus avoiding unwanted side reactions in sensitive syntheses. This dual nature – strong basicity and non-nucleophilicity – makes it an invaluable tool for chemists seeking precision in their reactions. Exploring detailed chemical properties of CAS 865-47-4 is crucial for any user.

Handling Potassium Tert-Butoxide requires strict adherence to safety protocols due to its reactivity. It is highly hygroscopic, meaning it readily absorbs moisture from the air, which can degrade its quality and alter its reactivity. Therefore, it must be stored in tightly sealed containers, preferably under an inert atmosphere such as nitrogen or argon, in a cool, dry place. When working with the solid, it is essential to use appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coats, to prevent skin and eye contact, as it can cause severe irritation or burns. The need to buy a pure sample and handle it under anhydrous conditions cannot be overstated.

The compound's solubility in polar aprotic solvents like Tetrahydrofuran (THF), Dimethyl Sulfoxide (DMSO), and Dimethylformamide (DMF) facilitates its use in various reaction media. However, its vigorous reaction with water necessitates careful exclusion of moisture. In situations where it may have absorbed moisture, re-purification methods might be employed, though generating it in situ is often preferred for laboratory use to ensure maximum activity. The importance of quality in chemical reagents cannot be stressed enough, especially when dealing with such reactive compounds. Purchasing from trusted sources ensures that the material meets the required specifications.

In summary, Potassium Tert-Butoxide (CAS 865-47-4) is a powerful and versatile reagent. Its unique properties as a strong, non-nucleophilic base make it indispensable in many areas of chemistry, from pharmaceutical synthesis to agrochemical production. However, its reactivity demands careful handling, proper storage, and a thorough understanding of its chemical properties. By prioritizing safety and sourcing high-quality material, users can confidently harness the capabilities of this essential chemical compound.